PMID- 1569133
OWN - NLM
STAT- MEDLINE
DCOM- 19920527
LR  - 20071114
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 12
IP  - 3
DP  - 1992 May
TI  - The CBF threshold and dynamics for focal cerebral infarction in spontaneously 
      hypertensive rats.
PG  - 359-70
AB  - Two strategies were used to estimate the blood flow threshold for focal cerebral 
      infarction in spontaneously hypertensive rats (SHRs) subjected to permanent 
      middle cerebral artery and common carotid artery occlusion (MCA/CCAO). The first 
      compared the volume of cortical infarction (24 h after ischemia onset) to the 
      volumes of ischemic cortex (image analysis of [14C]iodoantipyrine CBF 
      autoradiographs) perfused below CBF values less than 50 (VIC50) and less than 25 
      ml 100 g-1 min-1 (VIC25) at serial intervals during the first 3 h of ischemia. 
      The infarct process becomes irreversible within 3 h in this model. In the second, 
      measurements of CBF at the border separating normal from infarcted cortex at 24 h 
      after ischemia onset were used as an index of the threshold. During the first 3 h 
      of ischemia, VIC50 increased slightly to reach a maximum size at 3 h that closely 
      matched the 24 h infarct volume. VIC25, in contrast, consistently underestimated 
      the infarct volume by a factor of 2-3. CBF at the 24 h infarct border averaged 50 
      ml 100 g-1 min -1. Taken together, the results indicate that the CBF threshold 
      for infarction in SHRs approaches 50 ml 100 g-1 min-1 when ischemia persists for 
      greater than or equal to 3 h. This threshold value is approximately three times 
      higher than in primates. Since cortical neuronal density is also threefold 
      greater in rats than in primates, the higher injury threshold in the rat may 
      reflect a neuronal primacy in determining the brain's susceptibility to partial 
      ischemia.
FAU - Jacewicz, M
AU  - Jacewicz M
AD  - Department of Neurology and Neuroscience, Cornell University Medical Center, New 
      York, New York.
FAU - Tanabe, J
AU  - Tanabe J
FAU - Pulsinelli, W A
AU  - Pulsinelli WA
LA  - eng
GR  - NS-03346/NS/NINDS NIH HHS/United States
GR  - NS-07141/NS/NINDS NIH HHS/United States
GR  - NS-24302/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Animals
MH  - Autoradiography
MH  - Blood Flow Velocity
MH  - Brain Ischemia/*physiopathology
MH  - Cerebral Infarction/*physiopathology
MH  - *Cerebrovascular Circulation
MH  - Disease Models, Animal
MH  - Edema/physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Regional Blood Flow
MH  - Time Factors
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1038/jcbfm.1992.53 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 1992 May;12(3):359-70. doi: 10.1038/jcbfm.1992.53.