PMID- 15692249
OWN - NLM
STAT- MEDLINE
DCOM- 20050321
LR  - 20171101
IS  - 1424-8832 (Print)
IS  - 1424-8832 (Linking)
VI  - 33
IP  - 5-6
DP  - 2003 Sep-2004 Dec
TI  - Biological and clinical aspects of anticancer effects of antithrombotics.
PG  - 389-92
AB  - Hemostatic mechanisms play a role not only in cancer associated thrombotic 
      diathesis, but also in tumor growth and dissemination. Hence, inhibition of 
      fibrin formation has been considered a possible tool against the progression of 
      malignant disease. An antineoplastic effect of antithrombotic agents in various 
      experimental models (i.e. tumor cell in culture, experimental animals, and cancer 
      patients) has often been suggested. Anticoagulant drugs such as heparins and 
      vitamin K antagonists have been repeatedly tested in this context. However, 
      heparins have been more extensively studied. Several reports in animal models 
      demonstrate that heparin can reduce the primary tumor growth or its metastatic 
      spread. Clinical studies of thrombosis in cancer patients show that, besides 
      their role as antithrombotics, heparins may have beneficial effects on survival 
      in these patients, with a major role for low molecular-weight heparin (LMWHs) 
      compared to unfractionated heparin (UFH). More recently a number of prospective 
      randomized clinical trials of LMWH for survival as a primary end-point in cancer 
      patients have been conducted, showing favourable results.
FAU - Falanga, Anna
AU  - Falanga A
AD  - Department of Hematology-Oncology, Ospedali Riuniti di Bergamo, Bergamo, Italy. 
      annafalanga@yahoo.com
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Pathophysiol Haemost Thromb
JT  - Pathophysiology of haemostasis and thrombosis
JID - 101142710
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/*therapeutic use
MH  - Humans
MH  - Neoplasms/*drug therapy
MH  - Thrombosis/*drug therapy
RF  - 19
EDAT- 2005/02/05 09:00
MHDA- 2005/03/22 09:00
CRDT- 2005/02/05 09:00
PHST- 2005/02/05 09:00 [pubmed]
PHST- 2005/03/22 09:00 [medline]
PHST- 2005/02/05 09:00 [entrez]
AID - 83834 [pii]
AID - 10.1159/000083834 [doi]
PST - ppublish
SO  - Pathophysiol Haemost Thromb. 2003 Sep-2004 Dec;33(5-6):389-92. doi: 
      10.1159/000083834.