PMID- 15692252
OWN - NLM
STAT- MEDLINE
DCOM- 20050321
LR  - 20171101
IS  - 1424-8832 (Print)
IS  - 1424-8832 (Linking)
VI  - 33
IP  - 5-6
DP  - 2003 Sep-2004 Dec
TI  - New developments in diagnosis and treatment of heparin-induced thrombocytopenia.
PG  - 407-12
AB  - Heparin-induced thrombocytopenia (HIT) is a drug induced immune mediated 
      thrombocytopenia that affects up to 3% of patients treated with unfractionated 
      heparin (UFH). It is less frequent when low molecular weight heparins (LMWH) are 
      used. Fondaparinux does not seem to induce HIT. A functional and an antigen assay 
      should be performed to confirm the clinical diagnosis of HIT. Immediate cessation 
      of heparin and start of compatible anticoagulant is mandatory when HIT is 
      suspected clinically. Danaparoid (a heparinoid)and the direct thrombin inhibitors 
      lepirudin and argatroban are available for this purpose. Short-term reexposure 
      with heparin, for example during cardiopulmonary bypass, is possible in patients 
      with history of HIT, provided HIT antiodies are no longer detectable. In children 
      systematic data on treatment of HIT are lacking.
FAU - Lubenow, Norbert
AU  - Lubenow N
AD  - Institut fur Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universitat 
      Greifswald, Germany. lubenow@uni-greifswald.de
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Pathophysiol Haemost Thromb
JT  - Pathophysiology of haemostasis and thrombosis
JID - 101142710
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*adverse effects
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Thrombocytopenia/chemically induced/*diagnosis/*drug therapy
MH  - Thrombosis/*drug therapy
RF  - 56
EDAT- 2005/02/05 09:00
MHDA- 2005/03/22 09:00
CRDT- 2005/02/05 09:00
PHST- 2005/02/05 09:00 [pubmed]
PHST- 2005/03/22 09:00 [medline]
PHST- 2005/02/05 09:00 [entrez]
AID - 83837 [pii]
AID - 10.1159/000083837 [doi]
PST - ppublish
SO  - Pathophysiol Haemost Thromb. 2003 Sep-2004 Dec;33(5-6):407-12. doi: 
      10.1159/000083837.