PMID- 15693916
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20080528
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 16
IP  - 1
DP  - 2005 Feb
TI  - Efficacy and safety of modified Mai-Men-Dong-Tang for treatment of allergic 
      asthma.
PG  - 76-81
AB  - The aim of this study was to evaluate the efficacy and safety of a Chinese herbal 
      formula modified Mai-Men-Dong-Tang (mMMDT) for treatment of persistent, 
      mild-to-moderate asthma. A total of 100 asthmatic patients were enrolled and 
      assigned to three treatment groups in this double-blind, randomized, 
      placebo-controlled clinical trial. Over a period of 4 months, patients in groups 
      A and B received 80 and 40 mg/kg/day of mMMDT, while those in group C received a 
      placebo. Efficacy variables included changes in forced expiratory volume in 1 s 
      (FEV1), symptom score, serum total immunoglobulin E (IgE), and dust mite-specific 
      IgE. Safety assessments included complete blood count, and liver and kidney 
      function. Relative to baseline, significantly greater increases in FEV1 were 
      demonstrated for both A and B groups in comparison with the placebo-treated 
      analog (both p <0.05). Further, similar improvements in symptom score were 
      observed for both mMMDT treatment groups. The serum total IgE for group A showed 
      a decreasing tendency after treatment but no statistical difference was noted. 
      Furthermore, no drug-related adverse effects were reported. Blood test, and liver 
      and kidney function were within normal range during the study, with no marked 
      changes demonstrated over time. In conclusion, the Chinese herbal formula mMMDT 
      provided improvements in lung function and relieved asthma symptoms in our sample 
      of patients. Given its efficacy and safety, we consider mMMDT a credible 
      treatment regimen for persistent, mild-to-moderate asthma.
FAU - Hsu, Ching Hsaing
AU  - Hsu CH
AD  - Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan. 
      hsumd736@ms67.hinet.net
FAU - Lu, Chun Mei
AU  - Lu CM
FAU - Chang, Tung Ti
AU  - Chang TT
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Drugs, Chinese Herbal)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Asthma/*drug therapy
MH  - Child
MH  - Child, Preschool
MH  - Dose-Response Relationship, Drug
MH  - Double-Blind Method
MH  - Drugs, Chinese Herbal/adverse effects/*therapeutic use
MH  - Female
MH  - Forced Expiratory Volume/drug effects
MH  - Humans
MH  - Immunoglobulin E/blood/drug effects
MH  - Kidney Function Tests/methods
MH  - Liver Function Tests/methods
MH  - Male
MH  - Statistics, Nonparametric
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2005/02/08 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/02/08 09:00
PHST- 2005/02/08 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/02/08 09:00 [entrez]
AID - PAI230 [pii]
AID - 10.1111/j.1399-3038.2005.00230.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2005 Feb;16(1):76-81. doi: 
      10.1111/j.1399-3038.2005.00230.x.