PMID- 1569397
OWN - NLM
STAT- MEDLINE
DCOM- 19920526
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 175
IP  - 5
DP  - 1992 May 1
TI  - Monocyte chemotactic protein 1 is a potent activator of human basophils.
PG  - 1271-5
AB  - Cytokines belonging to the RANTES/SIS family are highly induced in a number of 
      pathophysiological processes such as autoimmune disorders, cancers, 
      atherosclerosis, and chronic inflammation. However, apart from their chemotactic 
      activity on monocytes and particular lymphocyte types, the biological activities 
      in the human system of this recently discovered cytokine family are largely 
      unknown. Here we report that one family member, described as monocyte chemotactic 
      protein 1 (MCP-1), strongly activates mature human basophils in a pertussis 
      toxin-sensitive manner. MCP-1 causes a rise in the cytosolic free calcium level 
      in basophils and monocytes, but not in other blood leukocyte types, and triggers 
      basophil degranulation at low concentrations (ED50 = 3-10 nM). Thus, MCP-1 is a 
      cytokine capable of directly inducing histamine release by basophils. 
      Furthermore, MCP-1 promotes the formation of leukotriene C4 by basophils 
      pretreated with interleukin 3 (IL-3), IL-5, or granulocyte/macrophage 
      colony-stimulating factor. MCP-1-induced basophil mediator release may play an 
      important role in allergic inflammation and other pathologies expressing MCP-1.
FAU - Bischoff, S C
AU  - Bischoff SC
AD  - Institute of Clinical Immunology, Inselspital, Bern, Switzerland.
FAU - Krieger, M
AU  - Krieger M
FAU - Brunner, T
AU  - Brunner T
FAU - Dahinden, C A
AU  - Dahinden CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Virulence Factors, Bordetella)
RN  - 820484N8I3 (Histamine)
RN  - EC 2.4.2.31 (Pertussis Toxin)
SB  - IM
MH  - Basophils/*immunology/metabolism
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*physiology
MH  - Histamine/metabolism
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Pertussis Toxin
MH  - Virulence Factors, Bordetella/pharmacology
PMC - PMC2119199
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
PMCR- 1992/11/01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
AID - 92235606 [pii]
AID - 10.1084/jem.175.5.1271 [doi]
PST - ppublish
SO  - J Exp Med. 1992 May 1;175(5):1271-5. doi: 10.1084/jem.175.5.1271.