PMID- 15694969
OWN - NLM
STAT- MEDLINE
DCOM- 20050616
LR  - 20151119
IS  - 0165-0378 (Print)
IS  - 0165-0378 (Linking)
VI  - 65
IP  - 1
DP  - 2005 Feb
TI  - Serum and placental interleukin-18 are elevated in preeclampsia.
PG  - 77-87
AB  - OBJECTIVES: Interleukin-18 (IL-18) is a proinflammatory cytokine with 
      pleiotrophic qualities and its roles in pregnancy, labor onset and pregnant 
      complications have been proposed. However, the alterations of serum and placental 
      IL-18 have been less investigated. The objective of the current investigation was 
      to detect IL-18 concentrations in serum and placentas from patients with 
      preeclampsia and women with normal pregnancy. METHODS: 27 patients with 
      preeclampsia and 28 women with normal pregnancy were recruited. Blood and 
      placental samples were taken and IL-18 concentrations in serum and placental 
      homogenate were analyzed by enzyme-linked immunosorbent assay (ELISA). The levels 
      of IL-18 in serum and placenta were compared between preeclampsia and control. 
      RESULTS: Both serum and placental levels of IL-18 were significantly increased in 
      preeclampsia as compared with control (P=0.014 and 0.003, respectively). Serum 
      and placental levels of IL-18 were not significantly different in preeclamptic 
      women who received dexomethasone and those who did not (P=0.223 and 0.330, 
      respectively). Serum and placental IL-18 levels were not significantly different 
      between preeclamptic women who delivered before 36 complete gestational weeks and 
      those who delivered after 36 complete weeks (P=0.616 and 0.869, respectively). 
      There were no significant differences in serum and placental IL-18 between women 
      with mild preeclampsia and those with severe preeclampsia (P=0.056 and 0.357, 
      respectively). CONCLUSIONS: Increased serum and placental levels of IL-18 were 
      observed in preeclampsia. Those associations may offer insight into the 
      pathogenesis of the disease.
FAU - Huang, Xiadi
AU  - Huang X
AD  - Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd., 
      Hangzhou, 310006, China.
FAU - Huang, Hefeng
AU  - Huang H
FAU - Dong, Minyue
AU  - Dong M
FAU - Yao, Qiwei
AU  - Yao Q
FAU - Wang, Hanzhi
AU  - Wang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis
MH  - Female
MH  - Humans
MH  - Interleukin-18/*analysis
MH  - Placenta/*chemistry/pathology
MH  - Pre-Eclampsia/*blood/pathology
MH  - Pregnancy
EDAT- 2005/02/08 09:00
MHDA- 2005/06/17 09:00
CRDT- 2005/02/08 09:00
PHST- 2004/03/17 00:00 [received]
PHST- 2004/08/01 00:00 [revised]
PHST- 2004/09/24 00:00 [accepted]
PHST- 2005/02/08 09:00 [pubmed]
PHST- 2005/06/17 09:00 [medline]
PHST- 2005/02/08 09:00 [entrez]
AID - S0165-0378(04)00147-0 [pii]
AID - 10.1016/j.jri.2004.09.003 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2005 Feb;65(1):77-87. doi: 10.1016/j.jri.2004.09.003.