PMID- 15695599
OWN - NLM
STAT- MEDLINE
DCOM- 20050920
LR  - 20081121
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 57
IP  - 4
DP  - 2005 Apr
TI  - The role of maternal factors, postnatal nutrition, weight gain, and gender in 
      regulation of serum IGF-I among preterm infants.
PG  - 605-10
AB  - IGF-I is important for somatic growth and development of the human fetus and 
      neonate. IGF-I also plays an important role in normal vascularization of human 
      retina, as it has been suggested that insufficient IGF-I may be a factor in the 
      development of retinopathy of prematurity. The principal regulator of the 
      bioavailability of IGF-I in the circulation is IGF binding protein 3 (IGFBP-3). 
      The aim of this study was to study factors associated with postnatal serum 
      concentrations of IGF-I and of IGFBP-3 in preterm infants from birth to an age 
      corresponding to 40 wk postmenstruation. We conducted a prospective, longitudinal 
      study in which we measured serum IGF-I and IGFBP-3 concentrations in 76 preterm 
      infants from birth (postmenstrual ages 23-32 wk) until discharge from hospital 
      around 40 wk. Information regarding nutrition, weight gain, maternal factors, and 
      treatment with corticosteroids were collected weekly. Variables found to be 
      associated with postnatal change over time of serum IGF-I and IGFBP-3 were 
      postmenstrual age (p<0.001), weight gain (standard deviation score) (p<0.001), 
      and enteral intake of protein (p<0.001). Male gender was associated with lower 
      IGF-I levels (p<0.001). The relationship between protein intake and IGF-I (and 
      also between protein intake and IGFBP-3) was positive, as was the relationship 
      between weight gain and IGF-I (and between weight gain and IGFBP-3). These 
      results indicate that the degree of prematurity, low enteral protein intake, male 
      gender, and slow weight gain are associated with a slower postnatal increase of 
      IGF-I in preterm infants.
FAU - Engstrom, Eva
AU  - Engstrom E
AD  - Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of 
      the Health of Women and Children, Goteborg, Sweden. eva.engstrom@vgregion.se
FAU - Niklasson, Aimon
AU  - Niklasson A
FAU - Wikland, Kerstin Albertsson
AU  - Wikland KA
FAU - Ewald, Uwe
AU  - Ewald U
FAU - Hellstrom, Ann
AU  - Hellstrom A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050204
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Birth Weight
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - *Infant Nutritional Physiological Phenomena
MH  - Infant, Newborn
MH  - Infant, Premature/*blood
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Longitudinal Studies
MH  - Male
MH  - Nutritional Status
MH  - Prospective Studies
MH  - Sex Factors
MH  - *Weight Gain
EDAT- 2005/02/08 09:00
MHDA- 2005/09/21 09:00
CRDT- 2005/02/08 09:00
PHST- 2005/02/08 09:00 [pubmed]
PHST- 2005/09/21 09:00 [medline]
PHST- 2005/02/08 09:00 [entrez]
AID - 01.PDR.0000155950.67503.BC [pii]
AID - 10.1203/01.PDR.0000155950.67503.BC [doi]
PST - ppublish
SO  - Pediatr Res. 2005 Apr;57(4):605-10. doi: 10.1203/01.PDR.0000155950.67503.BC. Epub 
      2005 Feb 4.