PMID- 15696305
OWN - NLM
STAT- MEDLINE
DCOM- 20050517
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 56
IP  - 12
DP  - 2005 Mar
TI  - Interchromosomal duplication of major histocompatibility complex class I regions 
      in rainbow trout (Oncorhynchus mykiss), a species with a presumably recent 
      tetraploid ancestry.
PG  - 878-93
AB  - Salmonid fishes are among the few animal taxa with a probable recent tetraploid 
      ancestor. The present study is the first to compare large (>100 kb) duplicated 
      genomic sequence fragments in such species. Two contiguous stretches with major 
      histocompatibility complex (MHC) class I genes were detected in a rainbow trout 
      BAC library, mapped and sequenced. The MHC class I duplicated regions, mapped by 
      fluorescence in situ hybridization (FISH), were shown to be located on different 
      metaphase chromosomes, Chr 14 and 18. Gene organization in both duplications is 
      similar to that in other fishes, in that the class I loci are tightly linked with 
      the PSMB8, PSMB9, PSMB10 and ABCB3 genes. Whereas one region, Onmy-IA, has a 
      classical MHC class I locus (UBA), Onmy-IB encodes only non-classical class Ib 
      proteins. The nucleotide diversity between the Onmy-IA and Onmy-IB noncoding 
      regions is about 14%. This suggests that the MHC class I duplication event has 
      occurred about 60 mya close to the time of an hypothesized ancestral tetraploid 
      event. The present article is the first convincing report on the co-existence of 
      two closely related MHC class I core regions on two different chromosomes. The 
      interchromosomal duplication and the homology levels are supportive of the 
      tetraploid model.
FAU - Shiina, Takashi
AU  - Shiina T
AD  - Department of Basic Medical Science and Molecular Medicine, Tokai University 
      School of Medicine, Isehara, Kanagawa 259-1193, Japan. 
      tshiina@is.icc.u-tokai.ac.jp
FAU - Dijkstra, Johannes Martinus
AU  - Dijkstra JM
FAU - Shimizu, Sayoko
AU  - Shimizu S
FAU - Watanabe, Atsushi
AU  - Watanabe A
FAU - Yanagiya, Kazuyo
AU  - Yanagiya K
FAU - Kiryu, Ikunari
AU  - Kiryu I
FAU - Fujiwara, Atushi
AU  - Fujiwara A
FAU - Nishida-Umehara, Chizuko
AU  - Nishida-Umehara C
FAU - Kaba, Yuuichi
AU  - Kaba Y
FAU - Hirono, Ikuo
AU  - Hirono I
FAU - Yoshiura, Yasutoshi
AU  - Yoshiura Y
FAU - Aoki, Takashi
AU  - Aoki T
FAU - Inoko, Hidetoshi
AU  - Inoko H
FAU - Kulski, Jerzy Kazimierz
AU  - Kulski JK
FAU - Ototake, Mitsuru
AU  - Ototake M
LA  - eng
SI  - GENBANK/AB162342
SI  - GENBANK/AB162343
SI  - GENBANK/AY525774
SI  - GENBANK/AY525775
SI  - GENBANK/AY525776
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050205
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Biological Evolution
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Bacterial/genetics
MH  - DNA/genetics
MH  - Exons
MH  - *Gene Duplication
MH  - *Genes, MHC Class I
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Models, Genetic
MH  - Molecular Sequence Data
MH  - Oncorhynchus mykiss/classification/*genetics/*immunology
MH  - Phylogeny
MH  - Polyploidy
MH  - Promoter Regions, Genetic
MH  - Sequence Homology, Amino Acid
MH  - Terminology as Topic
MH  - Transcription, Genetic
EDAT- 2005/02/08 09:00
MHDA- 2005/05/18 09:00
CRDT- 2005/02/08 09:00
PHST- 2004/08/16 00:00 [received]
PHST- 2004/11/17 00:00 [revised]
PHST- 2005/02/08 09:00 [pubmed]
PHST- 2005/05/18 09:00 [medline]
PHST- 2005/02/08 09:00 [entrez]
AID - 10.1007/s00251-004-0755-1 [doi]
PST - ppublish
SO  - Immunogenetics. 2005 Mar;56(12):878-93. doi: 10.1007/s00251-004-0755-1. Epub 2005 
      Feb 5.