PMID- 15696961
OWN - NLM
STAT- MEDLINE
DCOM- 20050316
LR  - 20191109
IS  - 1433-7398 (Print)
IS  - 1433-7398 (Linking)
VI  - 21
IP  - 1
DP  - 2004
TI  - Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.
PG  - 1-6
AB  - Hypoxia is a common feature of many malignant neoplasms and has been identified 
      as a major reason for the radioresistance of malignant tumor tissue. On the other 
      hand, the transcription factor hypoxia-inducible factor-1 (HIF-1) has attracted 
      attention because it is rapidly expressed when tissue oxygen tension is reduced, 
      thus playing the role of a hypoxic sensor. We investigated whether the level of 
      HIF-1 expression in glioblastoma (GBM) could be an indicator in a protocol for 
      postoperative radiotherapy. We immunohistologically evaluated the level of HIF-1 
      expression in 60 pathologically diagnosed GBMs. HIF-1 expression was positive in 
      all tumors. The progression-free survival of the group receiving only 
      conventional radiotherapy after surgery differed significantly according to the 
      level of HIF-1 expression. The results of this study suggest that the HIF-1 
      expression level can be an indicator of tumor radioresistance, and that prior 
      knowledge of the HIF-1 expression level allows the formulation of a protocol for 
      postoperative radiotherapy.
FAU - Irie, Nobuyuki
AU  - Irie N
AD  - Department of Neurosurgery, Nagasaki University Hospital, Nagasaki 852-8501, 
      Japan. nob-irie@net.nagasaki-u.ac.jp
FAU - Matsuo, Takayuki
AU  - Matsuo T
FAU - Nagata, Izumi
AU  - Nagata I
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Brain Tumor Pathol
JT  - Brain tumor pathology
JID - 9716507
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Protocols
MH  - Biomarkers, Tumor/*analysis
MH  - Brain Neoplasms/metabolism/mortality/*radiotherapy
MH  - Child
MH  - DNA-Binding Proteins/*biosynthesis
MH  - Disease-Free Survival
MH  - Female
MH  - Glioblastoma/metabolism/mortality/*radiotherapy
MH  - Humans
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Nuclear Proteins/*biosynthesis
MH  - Prognosis
MH  - Transcription Factors/*biosynthesis
EDAT- 2005/02/09 09:00
MHDA- 2005/03/17 09:00
CRDT- 2005/02/09 09:00
PHST- 2005/02/09 09:00 [pubmed]
PHST- 2005/03/17 09:00 [medline]
PHST- 2005/02/09 09:00 [entrez]
AID - 10.1007/BF02482169 [doi]
PST - ppublish
SO  - Brain Tumor Pathol. 2004;21(1):1-6. doi: 10.1007/BF02482169.