PMID- 15696974
OWN - NLM
STAT- MEDLINE
DCOM- 20050316
LR  - 20191109
IS  - 1433-7398 (Print)
IS  - 1433-7398 (Linking)
VI  - 21
IP  - 3
DP  - 2004
TI  - Chromosomal and genetic aberrations differ with meningioma subtype.
PG  - 127-33
AB  - Meningioma is one of the most common brain tumors, and a variety of genetic 
      abnormalities have been detected by the Southern blotting, polymerase chain 
      reaction (PCR), fluorescence in situ hybridization (FISH), and comparative 
      genomic hybridization (CGH) methods. However, these methods detect only a very 
      limited portion of the tumor genome or have a limited mapping resolution. In this 
      study, we used DNA microarray assay, which detects numerous genetic abnormalities 
      and analyzes a global assessment of molecular events in tumor cells. We analyzed 
      genomic DNA from 26 patients with benign meningiomas by GenoSensor Array 300 in 
      order to characterize gene amplifications, gene deletions, and chromosomal 
      information in the whole genome. Loss of chromosome 22q was found most 
      frequently. This chromosomal aberration was detected in 14 meningiomas (53.8%), 
      particularly in transitional and fibrous meningiomas. In meningothelial 
      meningiomas, amplification of INS and TCL1A was detected more frequently than in 
      other meningioma subtypes. DNA microarray assay revealed new genetic differences 
      among the meningioma subtypes, thus indicating that this novel technique is 
      useful for understanding tumor genesis and for the diagnosis of meningioma 
      subtype.
FAU - Wada, Kouichi
AU  - Wada K
AD  - Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 
      Yamadaoka, Suita, Osaka 565-0871, Japan.
FAU - Maruno, Motohiko
AU  - Maruno M
FAU - Suzuki, Tsuyoshi
AU  - Suzuki T
FAU - Kagawa, Naoki
AU  - Kagawa N
FAU - Hashiba, Tetsuo
AU  - Hashiba T
FAU - Fujimoto, Yasunori
AU  - Fujimoto Y
FAU - Hashimoto, Naoya
AU  - Hashimoto N
FAU - Izumoto, Shuichi
AU  - Izumoto S
FAU - Yoshimine, Toshiki
AU  - Yoshimine T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Brain Tumor Pathol
JT  - Brain tumor pathology
JID - 9716507
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/metabolism
MH  - Male
MH  - Meningeal Neoplasms/*genetics/metabolism/*pathology
MH  - Meningioma/*genetics/metabolism/*pathology
MH  - Middle Aged
MH  - *Oligonucleotide Array Sequence Analysis
EDAT- 2005/02/09 09:00
MHDA- 2005/03/17 09:00
CRDT- 2005/02/09 09:00
PHST- 2005/02/09 09:00 [pubmed]
PHST- 2005/03/17 09:00 [medline]
PHST- 2005/02/09 09:00 [entrez]
AID - 10.1007/BF02482188 [doi]
PST - ppublish
SO  - Brain Tumor Pathol. 2004;21(3):127-33. doi: 10.1007/BF02482188.