PMID- 15699241
OWN - NLM
STAT- MEDLINE
DCOM- 20050308
LR  - 20230318
IS  - 0002-9165 (Print)
IS  - 0002-9165 (Linking)
VI  - 81
IP  - 2
DP  - 2005 Feb
TI  - Effects of alcohol on insulin-like growth factor I and insulin-like growth factor 
      binding protein 3 in postmenopausal women.
PG  - 503-7
AB  - BACKGROUND: Increased circulating insulin-like growth factor I (IGF-I) 
      concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have 
      been associated with increased risk of several types of cancer, including colon, 
      prostate, and breast. Studies have suggested that alcohol may affect IGF-I or 
      IGFBP-3; however, controlled feeding studies to assess alcohol's effects on IGF-I 
      or IGFBP-3 have not been conducted. OBJECTIVE: To determine whether chronic, 
      moderate alcohol intake affects serum IGF-I or IGFBP-3 concentrations, we 
      performed a controlled, crossover feeding study. DESIGN: Fifty-three 
      postmenopausal women were randomly assigned to consume 0 g (control), 15 g (one 
      drink), or 30 g (2 drinks) alcohol daily for 8 wk and were rotated through the 
      other 2 intake levels in random order. All foods and beverages were provided 
      during the intervention. Individuals were monitored and calories adjusted to 
      maintain constant weight, and serum was collected at the end of each diet period. 
      RESULTS: Compared with the effects of 0 g alcohol/d, IGF-I concentrations were 
      nearly unchanged by 15 g alcohol/d (0.8%; 95% CI: -3.2%, 3.5%) but decreased 
      significantly by 4.9% (95% CI: -8.0%, -1.6%) with 30 g alcohol/d. IGFBP-3 
      concentrations significantly increased by 3.0% (95% CI: 0.4%, 5.6%) with 15 g 
      alcohol/d but did not increase significantly with 30 g/d (1.8%; 95% CI: -0.9%, 
      4.5%). CONCLUSIONS: To our knowledge, this is the first published controlled diet 
      study to find that in postmenopausal women, when weight is kept constant, alcohol 
      consumption reduces the amount of serum IGF-I potentially available for receptor 
      binding. These findings suggest that the effect of alcohol intake should be 
      considered in studies of IGF-I, IGFBP-3, and cancer in postmenopausal women.
FAU - Lavigne, Jackie A
AU  - Lavigne JA
AD  - National Cancer Institute, Bethesda, MD 20892-4264, USA. lavignej@mail.nih.gov
FAU - Baer, David J
AU  - Baer DJ
FAU - Wimbrow, Heather H
AU  - Wimbrow HH
FAU - Albert, Paul S
AU  - Albert PS
FAU - Brown, Ellen D
AU  - Brown ED
FAU - Judd, Joseph T
AU  - Judd JT
FAU - Campbell, William S
AU  - Campbell WS
FAU - Giffen, Carol A
AU  - Giffen CA
FAU - Dorgan, Joanne F
AU  - Dorgan JF
FAU - Hartman, Terryl J
AU  - Hartman TJ
FAU - Barrett, J Carl
AU  - Barrett JC
FAU - Hursting, Stephen D
AU  - Hursting SD
FAU - Taylor, Philip R
AU  - Taylor PR
LA  - eng
GR  - Y1-SC-8012/SC/NCI NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Clin Nutr
JT  - The American journal of clinical nutrition
JID - 0376027
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 3K9958V90M (Ethanol)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Alcohol Drinking/*metabolism
MH  - Cross-Over Studies
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/administration & dosage/*pharmacology
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*metabolism
MH  - Insulin-Like Growth Factor I/analysis/*metabolism
MH  - Middle Aged
MH  - Neoplasms/etiology
MH  - Postmenopause/*blood
EDAT- 2005/02/09 09:00
MHDA- 2005/03/09 09:00
CRDT- 2005/02/09 09:00
PHST- 2005/02/09 09:00 [pubmed]
PHST- 2005/03/09 09:00 [medline]
PHST- 2005/02/09 09:00 [entrez]
AID - S0002-9165(23)27567-X [pii]
AID - 10.1093/ajcn.81.2.503 [doi]
PST - ppublish
SO  - Am J Clin Nutr. 2005 Feb;81(2):503-7. doi: 10.1093/ajcn.81.2.503.