PMID- 15699390
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20091119
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 64
IP  - 3
DP  - 2005 Feb 8
TI  - Thymus changes in anti-MuSK-positive and -negative myasthenia gravis.
PG  - 536-8
AB  - Morphologic findings of thymuses from 32 anti-acetylcholine receptor 
      (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies 
      against the muscle-specific kinase (MuSK), were compared with those from 30 
      AChR-positive subjects. In contrast with the high frequency of thymic 
      hyperplastic changes in AChR-positive patients, in MuSK-positive subjects 
      histologic alterations were minimal, arguing against an intrathymic disease 
      pathogenesis. Since hyperplastic changes were seen in 35% of MuSK-negative 
      patients, the thymus could be involved in some of these cases.
FAU - Lauriola, L
AU  - Lauriola L
AD  - Catholic University, Rome, Italy.
FAU - Ranelletti, F
AU  - Ranelletti F
FAU - Maggiano, N
AU  - Maggiano N
FAU - Guerriero, M
AU  - Guerriero M
FAU - Punzi, C
AU  - Punzi C
FAU - Marsili, F
AU  - Marsili F
FAU - Bartoccioni, E
AU  - Bartoccioni E
FAU - Evoli, A
AU  - Evoli A
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
CIN - Neurology. 2005 Sep 13;65(5):782-3; author reply 782-3. PMID: 16157930
MH  - Adolescent
MH  - Adult
MH  - Antibody Specificity
MH  - Atrophy
MH  - Autoantibodies/*immunology
MH  - Autoantigens/*immunology
MH  - Child
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Lymphocyte Subsets/immunology
MH  - Male
MH  - Myasthenia Gravis/classification/*immunology/pathology/surgery
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - Single-Blind Method
MH  - Thymectomy
MH  - Thymus Gland/immunology/*pathology/surgery
EDAT- 2005/02/09 09:00
MHDA- 2005/09/20 09:00
CRDT- 2005/02/09 09:00
PHST- 2005/02/09 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/02/09 09:00 [entrez]
AID - 64/3/536 [pii]
AID - 10.1212/01.WNL.0000150587.71497.B6 [doi]
PST - ppublish
SO  - Neurology. 2005 Feb 8;64(3):536-8. doi: 10.1212/01.WNL.0000150587.71497.B6.