PMID- 15700122
OWN - NLM
STAT- MEDLINE
DCOM- 20050721
LR  - 20181113
IS  - 0020-9554 (Print)
IS  - 0020-9554 (Linking)
VI  - 46
IP  - 3
DP  - 2005 Mar
TI  - [Reflux esophagitis].
PG  - 315-27
AB  - Gastroesophageal reflux disease (GERD) is one of the most prevalent diseases in 
      the industrialized countries. Approximately 15-25% of adults suffer from reflux 
      symptoms, characterized mainly by heartburn and/or regurgitation. Currently, 
      antisecretory medication with proton pump inhibitors (PPI) or antireflux surgery 
      are the established options for GERD-treatment. PPI are the therapeutic gold 
      standard in acute, long-term or on-demand therapy of GERD. Since PPI do not 
      restore the antireflux barrier but merely suppress acid secretion a life-long 
      tablet adherence is required in most cases. In view of limitations of PPI and the 
      potential risks of laparoscopic surgery, several endoscopic antireflux techniques 
      were developed and may evolve as a valuable third option. However, so far 
      objective long-term data are lacking for choosing the appropriate patient who 
      will benefit most from endoluminal antireflux therapy.
FAU - Schiefke, I
AU  - Schiefke I
AD  - Medizinische Klinik und Poliklinik II, Universitat Leipzig.
FAU - Mossner, J
AU  - Mossner J
FAU - Caca, K
AU  - Caca K
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Refluxosophagitis.
PL  - Germany
TA  - Internist (Berl)
JT  - Der Internist
JID - 0264620
RN  - 0 (Antacids)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Adult
MH  - Antacids/administration & dosage
MH  - Anti-Ulcer Agents/administration & dosage
MH  - Clinical Trials as Topic
MH  - Cross-Sectional Studies
MH  - Esophagitis, Peptic/diagnosis/epidemiology/*therapy
MH  - Fundoplication
MH  - Gastric Acidity Determination
MH  - Humans
MH  - Laparoscopy
MH  - Prostheses and Implants
MH  - Proton Pump Inhibitors
MH  - Secondary Prevention
MH  - Suture Techniques
MH  - Treatment Outcome
EDAT- 2005/02/09 09:00
MHDA- 2005/07/22 09:00
CRDT- 2005/02/09 09:00
PHST- 2005/02/09 09:00 [pubmed]
PHST- 2005/07/22 09:00 [medline]
PHST- 2005/02/09 09:00 [entrez]
AID - 10.1007/s00108-005-1373-1 [doi]
PST - ppublish
SO  - Internist (Berl). 2005 Mar;46(3):315-27. doi: 10.1007/s00108-005-1373-1.