PMID- 15700656
OWN - NLM
STAT- MEDLINE
DCOM- 20050506
LR  - 20161124
IS  - 0035-7820 (Print)
IS  - 0035-7820 (Linking)
VI  - 55
IP  - 5
DP  - 2004
TI  - [Differential diagnosis of intra- and perilienal tumors by use of a RES-specific 
      MRI contrast agent].
PG  - 192-9
AB  - PURPOSE: To describe the additional benefit in detection and differential 
      diagnosis of peri- and intrasplenic tumors by use of an superparamagnetic iron 
      oxide contrast agent (SPIO). MATERIALS AND METHODS: We represent 7 patients with 
      known malignant tumors. Aim of the examination was the detection and 
      characterisation of intra- or perisplenic tumors. We performed T2w TSE breath 
      triggered sequences before and 10 min after application of SPIO and T1w Flash 2D 
      GRE sequences before and after SPIO and Gadopentetate dimeglumin application. All 
      images were presented to two radiologists, who were asked to asses the presence 
      and characterisation of tumors by using a five-point confidence scale. RESULTS: 
      In two patient intrasplenic hemangiomas were detected, intrasplenic lymphoma, 
      metastasis was excluded, respectively. In two patients perisplenic tumors were 
      diagnosed as gastrointestinal stroma tumors, confirmed by biopsy. In two patients 
      accessory spleens were identified and lymph node metastasis excluded. In one 
      patient an intrasplenic cyst was diagnosed. SPIO enhanced T2w images and 
      Gadopentetate dimeglumin enhanced T1w sequences were evaluated as superior. 
      CONCLUSION: The examination of the spleen by use of superparamagnetic iron oxides 
      offers additional abilities in depiction and charaterisation of intra- and 
      perisplenic tumors in first experiences. First clinical observations indicate 
      that a combination of SPIO enhanced T2w sequences and Gadopentetate dimeglumin 
      enhanced T1w dynamic sequences might be superior to other sequences in detection 
      and characterisation of splenic tumors.
FAU - Gaffke, Gunnar
AU  - Gaffke G
AD  - Klinik und Poliklinik fur Strahlenheilkunde der Charite, CampusVirchow Klinikum, 
      Medizinische Fakultat der Humboldt-Universitat zu Berlin. 
      gunnar.gaffke@charite.de
FAU - Stroszczynski, Christian
AU  - Stroszczynski C
FAU - Gnauck, Manuela
AU  - Gnauck M
FAU - Jost, Dominik
AU  - Jost D
FAU - Chmelik, Petra
AU  - Chmelik P
FAU - Ludwig, Wolf-Dieter
AU  - Ludwig WD
FAU - Gretschel, Stefan
AU  - Gretschel S
FAU - Felix, Roland
AU  - Felix R
LA  - ger
PT  - Journal Article
TT  - Differenzialdiagnose von Intra- und Perilienalen Tumoren mit Hilfe eines 
      RES-spezifischen MRT-Kontrastmittels.
PL  - Germany
TA  - Rontgenpraxis
JT  - Rontgenpraxis; Zeitschrift fur radiologische Technik
JID - 0404365
RN  - 0 (Contrast Media)
RN  - 0 (Dextrans)
RN  - 0 (Ferric Compounds)
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Oxides)
RN  - 0 (superparamagnetic blood pool agent)
RN  - E1UOL152H7 (Iron)
RN  - G6N3J05W84 (ferumoxides)
RN  - K2I13DR72L (Gadolinium DTPA)
RN  - XM0M87F357 (Ferrosoferric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Contrast Media
MH  - Dextrans
MH  - Diagnosis, Differential
MH  - Female
MH  - *Ferric Compounds
MH  - Ferrosoferric Oxide
MH  - *Gadolinium DTPA
MH  - Humans
MH  - *Image Enhancement/*methods
MH  - *Image Processing, Computer-Assisted
MH  - Injections, Intravenous
MH  - *Iron
MH  - Liver Neoplasms/diagnosis/pathology/secondary
MH  - *Magnetic Resonance Imaging
MH  - Magnetite Nanoparticles
MH  - Male
MH  - Middle Aged
MH  - Mononuclear Phagocyte System/*pathology
MH  - *Oxides
MH  - Sensitivity and Specificity
MH  - Spleen/pathology
MH  - Splenic Neoplasms/*diagnosis/pathology/secondary
EDAT- 2005/02/11 09:00
MHDA- 2005/05/07 09:00
CRDT- 2005/02/11 09:00
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2005/05/07 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
PST - ppublish
SO  - Rontgenpraxis. 2004;55(5):192-9.