PMID- 15701226
OWN - NLM
STAT- MEDLINE
DCOM- 20050429
LR  - 20220318
IS  - 0898-929X (Print)
IS  - 0898-929X (Linking)
VI  - 16
IP  - 10
DP  - 2004 Dec
TI  - Reflecting upon feelings: an fMRI study of neural systems supporting the 
      attribution of emotion to self and other.
PG  - 1746-72
AB  - Understanding one's own and other individual's emotional states is essential for 
      maintaining emotional equilibrium and strong social bonds. Although the neural 
      substrates supporting ref lection upon one's own feelings have been investigated, 
      no studies have directly examined attributions about the internal emotional 
      states of others to determine whether common or distinct neural systems support 
      these abilities. The present study sought to directly compare brain regions 
      involved in judging one's own, as compared to another individual's, emotional 
      state. Thirteen participants viewed mixed valence blocks of photos drawn from the 
      International Affective Picture System while whole-brain fMRI data were 
      collected. Preblock cues instructed participants to evaluate either their 
      emotional response to each photo, the emotional state of the central figure in 
      each photo, or (in a baseline condition) whether the photo was taken indoors or 
      outdoors. Contrasts indicated (1) that both self and other judgments activated 
      the medial prefrontal cortex (MPFC), the superior temporal gyrus, and the 
      posterior cingulate/precuneus, (2) that self judgments selectively activated 
      subregions of the MPFC and the left temporal cortex, whereas (3) other judgments 
      selectively activated the left lateral prefrontal cortex (including Broca's area) 
      and the medial occipital cortex. These results suggest (1) that self and other 
      evaluation of emotion rely on a network of common mechanisms centered on the 
      MPFC, which has been hypothesized to support mental state attributions in 
      general, and (2) that medial and lateral PFC regions selectively recruited by 
      self or other judgments may be involved in attention to, and elaboration of, 
      internally as opposed to externally generated information.
FAU - Ochsner, Kevin N
AU  - Ochsner KN
AD  - Department of Psychology, Columbia University, New York, NY 10027, USA. 
      ochsner@psych.columbia.edu
FAU - Knierim, Kyle
AU  - Knierim K
FAU - Ludlow, David H
AU  - Ludlow DH
FAU - Hanelin, Josh
AU  - Hanelin J
FAU - Ramachandran, Tara
AU  - Ramachandran T
FAU - Glover, Gary
AU  - Glover G
FAU - Mackey, Sean C
AU  - Mackey SC
LA  - eng
GR  - RR 09784/RR/NCRR NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cogn Neurosci
JT  - Journal of cognitive neuroscience
JID - 8910747
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Cerebral Cortex/*physiology
MH  - Consciousness/*physiology
MH  - Emotions/*physiology
MH  - Female
MH  - Humans
MH  - Judgment/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/physiology
MH  - Photic Stimulation
MH  - *Self Concept
MH  - Self-Assessment
MH  - Social Perception
EDAT- 2005/02/11 09:00
MHDA- 2005/04/30 09:00
CRDT- 2005/02/11 09:00
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2005/04/30 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
AID - 10.1162/0898929042947829 [doi]
PST - ppublish
SO  - J Cogn Neurosci. 2004 Dec;16(10):1746-72. doi: 10.1162/0898929042947829.