PMID- 15701462
OWN - NLM
STAT- MEDLINE
DCOM- 20050607
LR  - 20131121
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 7
IP  - 2
DP  - 2005 Mar 2
TI  - Enhanced oxidative stress in coronary heart disease and chronic heart failure as 
      indicated by an increased 8-epi-PGF(2alpha).
PG  - 167-72
AB  - The role of oxidation injury as an important factor in the pathophysiology of 
      cardiomyopathy (CMP) has recently gained increasing interest. Semiquantitative 
      analysis for isoprostane, 8-epi-prostaglandin F(2alpha) (8-epi-PGF(2alpha)), and 
      oxidised low-density lipoprotein (ox-LDL) of coronary vascular tissue samples 
      derived from CMP patients revealed an increased extent and intensity of uptake as 
      compared to the respective controls. To evaluate oxidative stress in vivo, we 
      examined plasma, serum, salivary, and urinary 8-epi-PGF(2alpha) in patients with 
      dilated CMP (n=20) and ischemic CMP (n=20) with decreased left ventricular 
      ejection fraction (LVEF). Patients with coronary heart disease (CHD) (n=20) and 
      20 healthy, age-matched, and sex-matched controls were investigated in parallel. 
      8-Epi-PGF(2alpha) levels were correlated with the functional severity of heart 
      failure [New York Heart Association (NYHA) classification] and LVEF. 
      8-Epi-PGF(2alpha) levels were matched according to risk factors (smoking and 
      hypercholesterolemia) and were significantly higher in patients with CMP as 
      compared to healthy controls and patients with CHD in all investigated 
      compartments. A positive correlation between NYHA stages and 8-epi-PGF(2alpha), 
      as well as a negative correlation to LVEF, could be demonstrated in a subgroup 
      analysis. These findings reflect the enhanced oxidation injury in patients with 
      CMP and, to a lesser extent, in CHD as compared to healthy controls, thus highly 
      indicating the relevance of oxidative stress for the pathogenesis and progression 
      of cardiovascular disease.
FAU - Wolfram, Roswitha
AU  - Wolfram R
AD  - Department of Angiology, Medical University of Vienna, Vienna, Austria.
FAU - Oguogho, Anthony
AU  - Oguogho A
FAU - Palumbo, Barbara
AU  - Palumbo B
FAU - Sinzinger, Helmut
AU  - Sinzinger H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
RN  - 27415-26-5 (8-epi-prostaglandin F2alpha)
RN  - B7IN85G1HY (Dinoprost)
SB  - IM
MH  - Adult
MH  - Angina Pectoris/*metabolism
MH  - Cardiomyopathy, Dilated/*metabolism
MH  - Case-Control Studies
MH  - Dinoprost/*analogs & derivatives/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*metabolism
MH  - Oxidative Stress/*physiology
MH  - Risk Factors
MH  - Saliva/*chemistry
MH  - Severity of Illness Index
EDAT- 2005/02/11 09:00
MHDA- 2005/06/09 09:00
CRDT- 2005/02/11 09:00
PHST- 2004/01/16 00:00 [received]
PHST- 2004/03/25 00:00 [revised]
PHST- 2004/05/05 00:00 [accepted]
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
AID - S138898420400162X [pii]
AID - 10.1016/j.ejheart.2004.05.007 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2005 Mar 2;7(2):167-72. doi: 10.1016/j.ejheart.2004.05.007.