PMID- 15701476
OWN - NLM
STAT- MEDLINE
DCOM- 20050607
LR  - 20220330
IS  - 1388-9842 (Print)
IS  - 1388-9842 (Linking)
VI  - 7
IP  - 2
DP  - 2005 Mar 2
TI  - Depression increasingly predicts mortality in the course of congestive heart 
      failure.
PG  - 261-7
AB  - BACKGROUND: Congestive heart failure (CHF) is frequently associated with 
      depression. However, the impact of depression on prognosis has not yet been 
      sufficiently established. AIMS: To prospectively investigate the influence of 
      depression on mortality in patients with CHF. METHODS: In 209 CHF patients 
      depression was assessed by the Hospital Anxiety and Depression Scale (HADS-D). 
      RESULTS: Compared to survivors (n=164), non-survivors (n=45) were characterized 
      by a higher New York Heart Association (NYHA) functional class (2.8+/-0.7 vs. 
      2.5+/-0.6), and a lower left ventricular ejection fraction (LVEF) (18+/-8 vs. 
      23+/-10%) and peakVO(2) (13.1+/-4.5 vs. 15.4+/-5.2 ml/kg/min) at baseline. 
      Furthermore, non-survivors had a higher depression score (7.5+/-4.0 vs. 
      6.1+/-4.3) (all P<0.05). After a mean follow-up of 24.8 months the depression 
      score was identified as a significant indicator of mortality (P<0.01). In 
      multivariate analysis the depression score predicted mortality independent from 
      NYHA functional class, LVEF and peakVO(2). Combination of depression score, LVEF 
      and peakVO(2) allowed for a better risk stratification than combination of LVEF 
      and peakVO(2) alone. The risk ratio for mortality in patients with an elevated 
      depression score (i.e. above the median) rose over time to 8.2 after 30 months 
      (CI 2.62-25.84). CONCLUSIONS: The depression score predicts mortality independent 
      of somatic parameters in CHF patients not treated for depression. Its prognostic 
      power increases over time and should, thus, be accounted for in risk 
      stratification and therapy.
FAU - Junger, Jana
AU  - Junger J
AD  - Department of General Internal and Psychosomatic Medicine, University of 
      Heidelberg, INF 410, D-69120 Heidelberg, Germany. 
      Jana_Juenger@med.uni-heidelberg.de
FAU - Schellberg, Dieter
AU  - Schellberg D
FAU - Muller-Tasch, Thomas
AU  - Muller-Tasch T
FAU - Raupp, Georg
AU  - Raupp G
FAU - Zugck, Christian
AU  - Zugck C
FAU - Haunstetter, Armin
AU  - Haunstetter A
FAU - Zipfel, Stephan
AU  - Zipfel S
FAU - Herzog, Wolfgang
AU  - Herzog W
FAU - Haass, Markus
AU  - Haass M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anxiety Disorders/*etiology
MH  - Depressive Disorder/*etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*mortality/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - ROC Curve
MH  - Survival Rate
EDAT- 2005/02/11 09:00
MHDA- 2005/06/09 09:00
CRDT- 2005/02/11 09:00
PHST- 2003/08/08 00:00 [received]
PHST- 2004/05/05 00:00 [revised]
PHST- 2004/05/24 00:00 [accepted]
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2005/06/09 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
AID - S1388-9842(04)00174-6 [pii]
AID - 10.1016/j.ejheart.2004.05.011 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2005 Mar 2;7(2):261-7. doi: 10.1016/j.ejheart.2004.05.011.