PMID- 15702570 OWN - NLM STAT- MEDLINE DCOM- 20050412 LR - 20191109 IS - 1040-1237 (Print) IS - 1040-1237 (Linking) VI - 16 IP - 4 DP - 2004 Oct-Dec TI - The overlap between personality disorders and major depressive disorder (MDD). PG - 217-24 AB - BACKGROUND: Research studies have focused attention on the importance of the comorbidity of personality disorders and depression. METHODS: The present review examines seven potential explanations for the overlap to clarify the nature of the relationship, if any, between depression and personality disorder diagnoses. RESULTS: There may be many explanations for the potential overlap of personality disorders (PD) and major depressive disorder (MDD). For example, the distinction between states and traits may not be as clear and definitive as suggested in the DSM-IV. In some cases, depression may influence personality pathology, and may even lead to personality disorders. In other cases, personality disorders may lead to MDD. CONCLUSION: Further research may clarify the nature of the relationship, if any, between depression and personality disorder diagnoses, as well as the relationship between comorbidity and treatment response. FAU - Farabaugh, Amy AU - Farabaugh A AD - The Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. afarabaugh@partners.org FAU - Mischoulon, David AU - Mischoulon D FAU - Fava, Maurizio AU - Fava M FAU - Guyker, Wendy AU - Guyker W FAU - Alpert, Jonathan AU - Alpert J LA - eng PT - Journal Article PT - Review PL - United States TA - Ann Clin Psychiatry JT - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists JID - 8911021 SB - IM MH - Comorbidity MH - Depressive Disorder, Major/diagnosis/*psychology MH - Diagnosis, Differential MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Humans MH - Personality Disorders/diagnosis/*psychology MH - Risk Factors RF - 77 EDAT- 2005/02/11 09:00 MHDA- 2005/04/13 09:00 CRDT- 2005/02/11 09:00 PHST- 2005/02/11 09:00 [pubmed] PHST- 2005/04/13 09:00 [medline] PHST- 2005/02/11 09:00 [entrez] AID - 10.1080/10401230490522043 [doi] PST - ppublish SO - Ann Clin Psychiatry. 2004 Oct-Dec;16(4):217-24. doi: 10.1080/10401230490522043.