PMID- 15703197
OWN - NLM
STAT- MEDLINE
DCOM- 20050712
LR  - 20171116
IS  - 0741-5400 (Print)
IS  - 0741-5400 (Linking)
VI  - 77
IP  - 5
DP  - 2005 May
TI  - Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human 
      dendritic cell subsets and CD4+ T cells.
PG  - 777-86
AB  - Dendritic cells (DCs) coordinate T cell responses by producing T cell-attracting 
      chemokines and by inducing the expression of chemokine receptors on T cells. 
      Scavenger receptor for phosphatidylserine and oxidized lipoprotein (SR-PSOX)/CXC 
      chemokine ligand 16 (CXCL16) is a unique chemokine that also functions as an 
      endocytic receptor and an adhesion molecule in its membrane-bound form. 
      SR-PSOX/CXCL16 is the only known ligand of CXC chemokine receptor 6 (CXCR6) that 
      is expressed on activated T cells and thus, may play an important role in 
      enhancing effector functions of T cells. Here, we investigated the expression of 
      SR-PSOX/CXCL16 on human DC subsets and that of CXCR6 on T cell subpopulations to 
      elucidate the dynamics of CXCL16/CXCR6 interaction in DC/T cell responses. 
      Membrane-bound SR-PSOX/CXCL16 was expressed on macrophages, monocyte-derived DCs, 
      and blood myeloid DCs, and the expression increased after DC maturation. Myeloid 
      antigen-presenting cells constitutively secreted SR-PSOX/CXCL16 for an extended 
      period, suggesting the involvement of CXCL16 in peripheral and lymphoid tissues. 
      Plasmacytoid DCs hardly expressed SR-PSOX/CXCL16 on their surfaces but secreted 
      significant amounts of SR-PSOX/CXCL16. A subset of CD4+ effector memory T (T(EM)) 
      cells constitutively expressed CXCR6, whereas central memory T cells (T(CM)) and 
      naive T cells did not. Upon stimulation with mature DCs, however, the expression 
      of CXCR6 on T(CM) cells was markedly up-regulated, whereas the expression on 
      naive T cells was induced only weakly. These results suggest that the interaction 
      between SR-PSOX/CXCL16 and CXCR6 plays an important role in enhancing T(CM) cell 
      responses by mature DCs in lymphoid tissues and in augmenting T(EM) cell 
      responses by macrophages in peripheral inflamed tissues.
FAU - Tabata, Sumie
AU  - Tabata S
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University, Sakyo-ku, Kyoto 606-8507, Japan.
FAU - Kadowaki, Norimitsu
AU  - Kadowaki N
FAU - Kitawaki, Toshio
AU  - Kitawaki T
FAU - Shimaoka, Takeshi
AU  - Shimaoka T
FAU - Yonehara, Shin
AU  - Yonehara S
FAU - Yoshie, Osamu
AU  - Yoshie O
FAU - Uchiyama, Takashi
AU  - Uchiyama T
LA  - eng
PT  - Journal Article
DEP - 20050209
PL  - England
TA  - J Leukoc Biol
JT  - Journal of leukocyte biology
JID - 8405628
RN  - 0 (CXCL16 protein, human)
RN  - 0 (CXCR6 protein, human)
RN  - 0 (Chemokine CXCL16)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, CXCR6)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Receptors, Virus)
SB  - IM
MH  - Antigen Presentation
MH  - CD4-Positive T-Lymphocytes/immunology/*metabolism
MH  - Cell Communication/immunology
MH  - Cell Differentiation/immunology
MH  - Chemokine CXCL16
MH  - Chemokines, CXC/*metabolism
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Humans
MH  - Kinetics
MH  - Membrane Proteins/*metabolism
MH  - Receptors, CXCR6
MH  - Receptors, Chemokine
MH  - Receptors, Cytokine/*metabolism
MH  - Receptors, G-Protein-Coupled/*metabolism
MH  - Receptors, Immunologic/*metabolism
MH  - Receptors, Scavenger
MH  - Receptors, Virus/*metabolism
EDAT- 2005/02/11 09:00
MHDA- 2005/07/13 09:00
CRDT- 2005/02/11 09:00
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2005/07/13 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
AID - jlb.1204733 [pii]
AID - 10.1189/jlb.1204733 [doi]
PST - ppublish
SO  - J Leukoc Biol. 2005 May;77(5):777-86. doi: 10.1189/jlb.1204733. Epub 2005 Feb 9.