PMID- 15703957
OWN - NLM
STAT- MEDLINE
DCOM- 20061002
LR  - 20181113
IS  - 0172-8172 (Print)
IS  - 0172-8172 (Linking)
VI  - 26
IP  - 3
DP  - 2006 Jan
TI  - The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti 
      children with oligoarticular juvenile idiopathic arthritis.
PG  - 224-8
AB  - We have determined the prevalence of human leukocyte antigen (HLA)-DR, DQ and DP 
      alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis 
      (OA-JIA) and healthy controls using the PCR-SSP (sequence specific primers) 
      method. The analysis took into account the presence of antinuclear antibodies and 
      chronic anterior uveitis. DRB1*03 (RR 2.20, P<0.001), DRB1*08 (RR 5.280, 
      P<0.026), DQA1*0501 (RR 1.930, P<0.001), DQB1*0304 (RR 7.920, P<0.002), DQB1*0501 
      (RR 3.080, P<0.007) and DPB1*0101 (RR 8.8, P<0.001) were the main HLA alleles 
      associated with OA-JIA in Kuwaiti Arabs in this study. DRB1*03 was detected in 
      71% of children with positive ANA, and in 50% of children with anterior uveitis. 
      DQA1 alleles *0501, *0103 and *0105 (P<0.001; 0.029 and 0.024 respectively) were 
      found to be associated with OA-JIA. In contrast, DQA1*0301 and DQA1*0302 alleles 
      appear to be protective in Kuwaiti children (RR 0.153, P<0.001 and RR 0.278, 
      P<0.016 respectively). The DQB1 alleles *0304 and *0501 were associated with 
      OA-JIA (P<0.002 and P<0.007 respectively). In the case of DPB1, only one allele 
      (*0101) was associated with OA-JIA (P<0.001). Most Kuwaiti Arab patients with 
      OA-JIA who carried a DQ or DP susceptibility allele also had an accompanying 
      DRB1*03 or *8 allele.
FAU - Alsaeid, K
AU  - Alsaeid K
AD  - Department of Pediatrics, Faculty of Medicine, Kuwait University, PO Box 24923, 
      Safat, 13110, Kuwait. khaledalsaeid@hotmail.com
FAU - Haider, M Z
AU  - Haider MZ
FAU - Sharma, P N
AU  - Sharma PN
FAU - Ayoub, E M
AU  - Ayoub EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20050210
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Antibodies, Antinuclear/blood
MH  - Arthritis, Juvenile/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Genotype
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Kuwait
MH  - Male
MH  - Uveitis, Anterior/complications
EDAT- 2005/02/11 09:00
MHDA- 2006/10/03 09:00
CRDT- 2005/02/11 09:00
PHST- 2004/05/11 00:00 [received]
PHST- 2004/09/25 00:00 [accepted]
PHST- 2005/02/11 09:00 [pubmed]
PHST- 2006/10/03 09:00 [medline]
PHST- 2005/02/11 09:00 [entrez]
AID - 10.1007/s00296-004-0553-y [doi]
PST - ppublish
SO  - Rheumatol Int. 2006 Jan;26(3):224-8. doi: 10.1007/s00296-004-0553-y. Epub 2005 
      Feb 10.