PMID- 15704530
OWN - NLM
STAT- MEDLINE
DCOM- 20050517
LR  - 20200225
IS  - 0160-9289 (Print)
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 28
IP  - 1
DP  - 2005 Jan
TI  - Monocyte chemoattractant protein-1 and recurrent cardiovascular events in 
      patients with stable coronary heart disease.
PG  - 31-5
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) participates in the 
      recruitment of mononuclear cells to the vessel wall. HYPOTHESIS: The aim of the 
      study was to evaluate the potential association between serum concentration of 
      MCP-1 and risk of future cardiovascular events in patients with chronic coronary 
      heart disease. METHODS: A nested case control design was used. Baseline serum 
      samples were taken from patients with coronary heart disease who were enrolled in 
      a secondary prevention study. The MCP-1 levels were measured in those patients 
      who had recurrent cardiovascular events during follow-up (n = 233) and compared 
      with levels in age- and gender-matched controls. RESULTS: There were no 
      differences in serum MCP-1 levels between cases and controls. The relative odds 
      of a recurrent cardiovascular event for each 1 standard deviation difference in 
      MCP-1 serum concentration (160 pg/ml) was 1.19 (95% confidence interval, 
      0.95-1.45). No increase in the relative odds for recurrent cardiovascular events 
      was observed per increasing tertiles of MCP-1 concentrations. CONCLUSION: 
      Elevated MCP-1 levels are not associated with long-term risk of cardiovascular 
      events in patients with stable coronary disease.
FAU - Haim, Moti
AU  - Haim M
AD  - Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, 
      Israel. motih@netvision.net.il
FAU - Tanne, David
AU  - Tanne D
FAU - Boyko, Valentina
AU  - Boyko V
FAU - Reshef, Tamar
AU  - Reshef T
FAU - Goldbourt, Uri
AU  - Goldbourt U
FAU - Battler, Alexander
AU  - Battler A
FAU - Mekori, Yoseph A
AU  - Mekori YA
FAU - Behar, Solomon
AU  - Behar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Chronic Disease
MH  - Coronary Disease/*blood/complications
MH  - Death, Sudden, Cardiac/etiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/etiology
MH  - Odds Ratio
MH  - Prospective Studies
MH  - Recurrence
MH  - Risk Assessment
MH  - Stroke/*blood/etiology
MH  - Time Factors
PMC - PMC6654341
EDAT- 2005/02/12 09:00
MHDA- 2005/05/18 09:00
PMCR- 2006/12/05
CRDT- 2005/02/12 09:00
PHST- 2005/02/12 09:00 [pubmed]
PHST- 2005/05/18 09:00 [medline]
PHST- 2005/02/12 09:00 [entrez]
PHST- 2006/12/05 00:00 [pmc-release]
AID - CLC4960280109 [pii]
AID - 10.1002/clc.4960280109 [doi]
PST - ppublish
SO  - Clin Cardiol. 2005 Jan;28(1):31-5. doi: 10.1002/clc.4960280109.