PMID- 15705424
OWN - NLM
STAT- MEDLINE
DCOM- 20060131
LR  - 20201212
IS  - 0065-2776 (Print)
IS  - 0065-2776 (Linking)
VI  - 86
DP  - 2005
TI  - Regulation of antigen presentation and cross-presentation in the dendritic cell 
      network: facts, hypothesis, and immunological implications.
PG  - 241-305
AB  - Dendritic cells (DCs) are central to the maintenance of immunological tolerance 
      and the initiation and control of immunity. The antigen-presenting properties of 
      DCs enable them to present a sample of self and foreign proteins, contained 
      within an organism at any given time, to the T-cell repertoire. DCs achieve this 
      communication with T cells by displaying antigenic peptides bound to MHC I and 
      MHC II molecules. Here we review the studies carried out over the past 15 years 
      to characterize these antigen presentation mechanisms, emphasizing their 
      significance in relation to DC function in vivo. The life cycles of different DC 
      populations found in vivo are described. Furthermore, we provide a critical 
      assessment of the studies that examine the mechanisms controlling DC MHC class II 
      antigen presentation, which have often reached contradictory conclusions. 
      Finally, we review findings pertaining to the biological mechanisms that enable 
      DCs to present exogenous antigens on their MHC class I molecules, a process known 
      as cross-presentation. Throughout, we highlight what we consider to be major 
      knowledge gaps in the field and speculate on possible directions for future 
      research.
FAU - Wilson, Nicholas S
AU  - Wilson NS
AD  - Immunology Division and The Cooperative Research Center for Vaccine Technology, 
      The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 
      3050, Australia.
FAU - Villadangos, Jose A
AU  - Villadangos JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Immunol
JT  - Advances in immunology
JID - 0370425
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Antigen-Presenting Cells/immunology
MH  - Cross-Priming/*immunology
MH  - Dendritic Cells/*immunology
MH  - Histocompatibility Antigens Class I/metabolism
MH  - Humans
MH  - Immune Tolerance
RF  - 500
EDAT- 2005/02/12 09:00
MHDA- 2006/02/01 09:00
CRDT- 2005/02/12 09:00
PHST- 2005/02/12 09:00 [pubmed]
PHST- 2006/02/01 09:00 [medline]
PHST- 2005/02/12 09:00 [entrez]
AID - S0065277604860073 [pii]
AID - 10.1016/S0065-2776(04)86007-3 [doi]
PST - ppublish
SO  - Adv Immunol. 2005;86:241-305. doi: 10.1016/S0065-2776(04)86007-3.