PMID- 15707012
OWN - NLM
STAT- MEDLINE
DCOM- 20050928
LR  - 20231213
IS  - 0869-2092 (Print)
IS  - 0869-2092 (Linking)
VI  - 67
IP  - 6
DP  - 2004 Nov-Dec
TI  - [The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist 
      nociceptin].
PG  - 32-5
AB  - Prophylactic intravenous (i.v.) injections of a selective agonist of ORL1 
      receptors nociceptin (orphanin FQ) in a dose of 0.4 mg/kg prevented the 
      development of aconitine-induced arrhythmia in rats narcotized with diethyl ether 
      or chloralose. Pretreatment with L-NAME (50 mg/kg) completely abolished this 
      effect of orphanin FQ, while the pretreatment with indomethacin (10 mg/kg) only 
      attenuated the agonist effect, rather than abolished it completely. At the same 
      time, pretreatment with hexamethonium (10 mg/kg) or glibenclamide (3 mg/kg) had 
      no effect on the nociceptin-dependent cardiac tolerance to the arrhythmogenic 
      action of aconitine. Intracerebroventricular (i.c.v.) infusion of orphanin FQ (36 
      microg) also prevented the onset of aconitine-induced arrhythmia, but this effect 
      was completely abolished by hexamethonium. It is concluded that the 
      antiarrhythmic action of nociceptin with respect to aconitine-induced arrhythmia 
      upon i.v. and i.c.v. administration is explained by different mechanisms. In the 
      former case, the effect of orphanin FQ is related to the activation of NO 
      synthase and cyclooxygenase, while the central action involves the vegetative 
      nervous system.
FAU - Maslov, L N
AU  - Maslov LN
FAU - Krylatov, A V
AU  - Krylatov AV
FAU - Lishmanov, Iu B
AU  - Lishmanov IuB
FAU - Galo, G
AU  - Galo G
FAU - Ma, K
AU  - Ma K
FAU - Stakheev, D L
AU  - Stakheev DL
LA  - rus
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - K mekhanizmu aniaritmicheskogo deistviia endogennogo agonista ORL! retseptorov 
      Notsitseptina.
PL  - Russia (Federation)
TA  - Eksp Klin Farmakol
JT  - Eksperimental'naia i klinicheskaia farmakologiia
JID - 9215981
RN  - 0 (Anti-Arrhythmia Agents)
RN  - 0 (Opioid Peptides)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Vasodilator Agents)
RN  - 0 (Nociceptin Receptor)
RN  - 0 (Oprl protein, rat)
SB  - IM
MH  - Animals
MH  - Anti-Arrhythmia Agents/*metabolism
MH  - Arrhythmias, Cardiac/chemically induced/*physiopathology
MH  - Male
MH  - Opioid Peptides/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Opioid/*agonists
MH  - Vasodilator Agents/*administration & dosage
MH  - Nociceptin Receptor
MH  - Nociceptin
EDAT- 2005/02/15 09:00
MHDA- 2005/09/29 09:00
CRDT- 2005/02/15 09:00
PHST- 2005/02/15 09:00 [pubmed]
PHST- 2005/09/29 09:00 [medline]
PHST- 2005/02/15 09:00 [entrez]
PST - ppublish
SO  - Eksp Klin Farmakol. 2004 Nov-Dec;67(6):32-5.