PMID- 15707679
OWN - NLM
STAT- MEDLINE
DCOM- 20050627
LR  - 20141120
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 154
IP  - 2
DP  - 2005 Feb 8
TI  - Developmental expression of glucokinase in rat hypothalamus.
PG  - 255-8
AB  - Neurons in the hypothalamus sense changes in glucose concentration. Glucokinase 
      (GK), a key enzyme for pancreatic (beta)-cell glucose sensing, was found in both 
      the embryonic and adult hypothalamus. GK activity accounted for approximately 20% 
      of total hexokinase (HK) activity in both embryonic and adult hypothalamus with 
      no activity measured in cortical samples, indicating that glucose sensing in the 
      hypothalamus initiates early in development and precedes the maturation of 
      glucose signaling in liver.
FAU - Sutherland, Vicki L
AU  - Sutherland VL
AD  - Department of Physiology, Arizona Health Sciences Center, University of Arizona, 
      Tucson, AZ 85724, USA.
FAU - McReynolds, Matthew
AU  - McReynolds M
FAU - Tompkins, Linda S
AU  - Tompkins LS
FAU - Brooks, Heddwen L
AU  - Brooks HL
FAU - Lynch, Ronald M
AU  - Lynch RM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20041209
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.2 (Glucokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Blotting, Northern/methods
MH  - Blotting, Southern/methods
MH  - DNA, Complementary/metabolism
MH  - Embryo, Mammalian
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Glucokinase/genetics/*metabolism
MH  - Glucose/analysis
MH  - Hexokinase/metabolism
MH  - Hypothalamus/cytology/embryology/*enzymology/growth & development
MH  - In Vitro Techniques
MH  - Polymerase Chain Reaction/methods
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2005/02/15 09:00
MHDA- 2005/06/28 09:00
CRDT- 2005/02/15 09:00
PHST- 2004/07/15 00:00 [received]
PHST- 2004/11/04 00:00 [revised]
PHST- 2004/11/07 00:00 [accepted]
PHST- 2005/02/15 09:00 [pubmed]
PHST- 2005/06/28 09:00 [medline]
PHST- 2005/02/15 09:00 [entrez]
AID - S0165-3806(04)00339-6 [pii]
AID - 10.1016/j.devbrainres.2004.11.001 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2005 Feb 8;154(2):255-8. doi: 
      10.1016/j.devbrainres.2004.11.001. Epub 2004 Dec 9.