PMID- 1570800 OWN - NLM STAT- MEDLINE DCOM- 19920522 LR - 20180330 IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 55 IP - 5 DP - 1992 May TI - Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. PG - 934-42 AB - To study the influence of diet composition on regulation of body weight, we fed 21 weight-stable subjects (11 lean, 10 obese) high-carbohydrate (HC) and high-fat (HF) diets for 1 wk each. Although diet composition was fixed, total energy intake was unrestricted. Subjects had a higher energy intake on the HF (11,039 +/- 2700 kJ/d) than on the HC (10,672 +/- 2617 kJ/d) diet (P less than 0.05), but energy expenditure was not different between diets. On day 7 of the HC diet, carbohydrate (CHO) oxidation was significantly related to CHO intake with the slope of the regression line 0.99, suggesting that overall CHO balance was near zero. However, the slope of the regression line was greater for obese than for lean subjects. On day 7 of the HF diet, fat oxidation was significantly related to fat intake but the slope of the line was 0.50, suggesting that overall fat balance was positive. However, this relationship was due entirely to lean subjects, with obese subjects showing no relationship between fat intake and oxidation. FAU - Thomas, C D AU - Thomas CD AD - Department of Pediatrics, Vanderbilt University, Nashville, TN 37232. FAU - Peters, J C AU - Peters JC FAU - Reed, G W AU - Reed GW FAU - Abumrad, N N AU - Abumrad NN FAU - Sun, M AU - Sun M FAU - Hill, J O AU - Hill JO LA - eng GR - DK26657/DK/NIDDK NIH HHS/United States GR - DK42549/DK/NIDDK NIH HHS/United States GR - RR00095/RR/NCRR NIH HHS/United States PT - Clinical Trial PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Carbohydrates) RN - 0 (Dietary Fats) RN - 0 (Dietary Proteins) SB - IM MH - Adult MH - Body Composition MH - Body Weight MH - Calorimetry MH - Dietary Carbohydrates/*administration & dosage/metabolism MH - Dietary Fats/*administration & dosage/metabolism MH - Dietary Proteins/administration & dosage/metabolism MH - Eating MH - *Energy Intake MH - *Energy Metabolism MH - Female MH - Humans MH - Male MH - Obesity/*metabolism MH - Oxidation-Reduction MH - Random Allocation MH - Regression Analysis EDAT- 1992/05/01 00:00 MHDA- 1992/05/01 00:01 CRDT- 1992/05/01 00:00 PHST- 1992/05/01 00:00 [pubmed] PHST- 1992/05/01 00:01 [medline] PHST- 1992/05/01 00:00 [entrez] AID - 10.1093/ajcn/55.5.934 [doi] PST - ppublish SO - Am J Clin Nutr. 1992 May;55(5):934-42. doi: 10.1093/ajcn/55.5.934.