PMID- 15708443
OWN - NLM
STAT- MEDLINE
DCOM- 20050509
LR  - 20071114
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 26
IP  - 5
DP  - 2005 May
TI  - Caloric restriction does not reverse aging-related changes in hippocampal BDNF.
PG  - 683-8
AB  - Caloric restriction (CR) can attenuate the aging-related decline in learning and 
      memory in rats. Understanding the mechanisms underlying this effect could lead to 
      therapies for human memory impairment. We tested the hypotheses that aging is 
      associated with a decline in hippocampal brain-derived neurotrophic factor 
      (BDNF), a growth factor that enhances learning and memory, and that CR increases 
      hippocampal BDNF. We compared BDNF protein levels in hippocampal subregions of 
      young, middle-aged and old rats fed CR or ad libitum (AL) diets. Mean BDNF levels 
      in the dentate gyrus and CA3 did not differ with diet but increased with age. In 
      CA1, BDNF levels were slightly higher in CR than AL rats at middle and old age 
      but did not change across lifespan. These data suggest that mnemonic impairments 
      with age do not reflect a decrease in hippocampal BDNF. Furthermore, if CRs 
      attenuation of aging-related memory changes is mediated by BDNF, then it must be 
      through a small, CA1-specific increase and does not involve reversal of an 
      aging-related decline in BDNF.
FAU - Newton, Isabel G
AU  - Newton IG
AD  - Department of Neurobiology, Medical Center Boulevard, Winston-Salem, NC 
      27157-1010, USA. inewton@wfubmc.edu
FAU - Forbes, M Elizabeth
AU  - Forbes ME
FAU - Legault, Claudine
AU  - Legault C
FAU - Johnson, James E
AU  - Johnson JE
FAU - Brunso-Bechtold, Judy K
AU  - Brunso-Bechtold JK
FAU - Riddle, David R
AU  - Riddle DR
LA  - eng
GR  - AG019886/AG/NIA NIH HHS/United States
GR  - AG11370/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Aging/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Caloric Restriction/*methods
MH  - Chromatography, High Pressure Liquid/methods
MH  - Cohort Studies
MH  - Electrochemistry/methods
MH  - Hippocampus/anatomy & histology/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
EDAT- 2005/02/15 09:00
MHDA- 2005/05/10 09:00
CRDT- 2005/02/15 09:00
PHST- 2003/12/17 00:00 [received]
PHST- 2004/05/26 00:00 [revised]
PHST- 2004/06/16 00:00 [accepted]
PHST- 2005/02/15 09:00 [pubmed]
PHST- 2005/05/10 09:00 [medline]
PHST- 2005/02/15 09:00 [entrez]
AID - S0197-4580(04)00232-5 [pii]
AID - 10.1016/j.neurobiolaging.2004.06.005 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2005 May;26(5):683-8. doi: 10.1016/j.neurobiolaging.2004.06.005.