PMID- 15710084
OWN - NLM
STAT- MEDLINE
DCOM- 20050426
LR  - 20191026
IS  - 0210-5705 (Print)
IS  - 0210-5705 (Linking)
VI  - 28
IP  - 2
DP  - 2005 Feb
TI  - [Gastroesophageal reflux disease refractory to esomeprazole].
PG  - 65-7
AB  - Resistance to proton pump inhibitors (PPI) in gastroesophageal reflux disease 
      (GERD), which has been described in patients treated with omeprazole, could 
      explain some exceptional cases of treatment failure and the need for surgery. The 
      objective test of resistance to PPI is obtained with 24-hour intragastric 
      pH-metry performed during treatment. A gastric pH of less than 4 for more than 
      50% of recording time indicates resistance. We present a patient with non-erosive 
      GERD and treatment failure to omeprazole and proven resistance to esomeprazole 
      which, to our knowledge, has only been reported in patients with Barrett's 
      esophagus.
FAU - Velasco, M J
AU  - Velasco MJ
AD  - Servicio de Medicina Digestiva, Hospital Universitari La Fe, Valencia, Spain. 
      manueljosev@hotmail.com
FAU - Ortiz, V
AU  - Ortiz V
FAU - Ponce, J
AU  - Ponce J
LA  - spa
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Enfermedad por reflujo gastroesofagico refractaria a esomeprazol.
PL  - Spain
TA  - Gastroenterol Hepatol
JT  - Gastroenterologia y hepatologia
JID - 8406671
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - KG60484QX9 (Omeprazole)
RN  - N3PA6559FT (Esomeprazole)
SB  - IM
MH  - Adult
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Esomeprazole
MH  - Gastric Acidity Determination
MH  - Gastroesophageal Reflux/diagnosis/*drug therapy
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Male
MH  - Omeprazole/*therapeutic use
MH  - Proton Pump Inhibitors
MH  - Treatment Failure
EDAT- 2005/02/16 09:00
MHDA- 2005/04/27 09:00
CRDT- 2005/02/16 09:00
PHST- 2005/02/16 09:00 [pubmed]
PHST- 2005/04/27 09:00 [medline]
PHST- 2005/02/16 09:00 [entrez]
AID - 13070702 [pii]
AID - 10.1157/13070702 [doi]
PST - ppublish
SO  - Gastroenterol Hepatol. 2005 Feb;28(2):65-7. doi: 10.1157/13070702.