PMID- 15710474
OWN - NLM
STAT- MEDLINE
DCOM- 20050428
LR  - 20181201
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 160
IP  - 1-2
DP  - 2005 Mar
TI  - Tumor necrosis factor-alpha and interleukin-6 regulate secretion of brain-derived 
      neurotrophic factor in human monocytes.
PG  - 204-9
AB  - Activated macrophages have been shown to produce brain-derived neurotrophic 
      factor (BDNF) in diseases such as multiple sclerosis (MS) or allergic bronchial 
      asthma (BA). However, there is little data on BDNF regulation in these cells. We 
      demonstrate that unstimulated human peripheral blood monocytes, but not 
      lymphocytes, constitutively secrete BDNF. IL-6 and TNF-alpha specifically 
      enhanced BDNF secretion in monocytes, whereas typical Th1- and Th2-cytokines did 
      not show any effect. None of the cytokines induced BDNF secretion in T- or 
      B-cells. Thus, our data provide evidence that IL-6 and TNF-alpha represent a 
      specific link between monocyte infiltration and neuronal changes in inflammatory 
      diseases.
FAU - Schulte-Herbruggen, Olaf
AU  - Schulte-Herbruggen O
AD  - Department of Neurology, Charite, Humboldt University, Berlin, Germany.
FAU - Nassenstein, Christina
AU  - Nassenstein C
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
FAU - Quarcoo, David
AU  - Quarcoo D
FAU - Renz, Harald
AU  - Renz H
FAU - Braun, Armin
AU  - Braun A
LA  - eng
PT  - Journal Article
DEP - 20041222
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adjuvants, Immunologic/pharmacology
MH  - Adult
MH  - Asthma/immunology
MH  - B-Lymphocytes/metabolism
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics/*metabolism
MH  - Cell-Free System/metabolism
MH  - Cells, Cultured
MH  - Cytokines/pharmacology
MH  - Humans
MH  - Inflammation Mediators/pharmacology
MH  - Interleukin-6/*pharmacology
MH  - Leukocytes, Mononuclear/immunology/metabolism
MH  - Monocytes/*immunology/*metabolism
MH  - Multiple Sclerosis/immunology
MH  - RNA, Messenger/biosynthesis
MH  - T-Lymphocytes/metabolism
MH  - Tumor Necrosis Factor-alpha/*pharmacology
MH  - Up-Regulation/immunology
EDAT- 2005/02/16 09:00
MHDA- 2005/04/29 09:00
CRDT- 2005/02/16 09:00
PHST- 2004/07/23 00:00 [received]
PHST- 2004/10/25 00:00 [revised]
PHST- 2004/10/25 00:00 [accepted]
PHST- 2005/02/16 09:00 [pubmed]
PHST- 2005/04/29 09:00 [medline]
PHST- 2005/02/16 09:00 [entrez]
AID - S0165-5728(04)00403-5 [pii]
AID - 10.1016/j.jneuroim.2004.10.026 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2005 Mar;160(1-2):204-9. doi: 10.1016/j.jneuroim.2004.10.026. 
      Epub 2004 Dec 22.