PMID- 15712014
OWN - NLM
STAT- MEDLINE
DCOM- 20050421
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 56
IP  - 11
DP  - 2005 Feb
TI  - HLA class II alleles and measles virus-specific cytokine immune response 
      following two doses of measles vaccine.
PG  - 798-807
AB  - Measles virus-specific T cells and the production of cytokines play a critical 
      role in the immune response following measles immunization. To understand the 
      genetic factors that influence variation in IFN-gamma and IL-4 responses 
      following measles immunization and to provide insight into the factors 
      influencing both cellular and humoral immunity to measles, we assessed 
      associations between human leukocyte antigen (HLA) class II genes and 
      measles-specific Th1 and Th2-type cytokine responses in peripheral blood 
      lymphocytes from 339 children previously vaccinated with two doses of 
      measles-mumps-rubella vaccine (MMR-II). Median values for measles-specific 
      IFN-gamma and IL-4 secretion levels were 40.73 and 9.71 pg/ml, respectively. The 
      global tests suggested associations between measles-specific IFN-gamma response 
      and alleles of the DRB1 and DQB1 loci (P=0.07 and P=0.02, respectively). 
      Specifically, DRB1*0301, *0901, and *1501 alleles were significantly associated 
      with IFN-gamma secretion. The alleles that suggested evidence of an HLA 
      association with IL-4 secretion were DRB1*0103, *0701, and *1101. Th1 cytokine 
      responses and DQB1 allele associations revealed that the alleles with the 
      strongest association with IFN-gamma secretion were DQB1*0201, *0303, *0402, and 
      *0602. Specific alleles with a suggestive association with low measles-specific 
      Th2 cytokine responses were DQB1*0202 and *0503. In addition, DPB1*0101, *0201, 
      and *0601 alleles provided suggestive evidence of an HLA association with 
      measles-induced IFN-gamma response, while DPB1*0501 was associated with an IL-4 
      response. These data suggest that IFN-gamma and IL-4 cytokine responses to 
      measles may be genetically restricted in part by HLA class II genes, which in 
      turn can restrict the cellular immune response to measles vaccine.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
AD  - Mayo Vaccine Research Group, Mayo Clinic and Foundation, Guggenheim 611C, 200 1st 
      Street SW, Rochester, MN 55905, USA.
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Ryan, Jenna E
AU  - Ryan JE
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - AI 33144/AI/NIAID NIH HHS/United States
GR  - AI 48793/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050127
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Measles Vaccine)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Cytokines/immunology/*metabolism
MH  - Female
MH  - Histocompatibility Antigens Class II/*immunology
MH  - Humans
MH  - Immune System/*drug effects/immunology/metabolism
MH  - Interferon-gamma/immunology/metabolism
MH  - Male
MH  - Measles Vaccine/immunology/*pharmacology
MH  - Measles virus/immunology
EDAT- 2005/02/16 09:00
MHDA- 2005/04/22 09:00
CRDT- 2005/02/16 09:00
PHST- 2004/08/13 00:00 [received]
PHST- 2004/11/17 00:00 [revised]
PHST- 2005/02/16 09:00 [pubmed]
PHST- 2005/04/22 09:00 [medline]
PHST- 2005/02/16 09:00 [entrez]
AID - 10.1007/s00251-004-0756-0 [doi]
PST - ppublish
SO  - Immunogenetics. 2005 Feb;56(11):798-807. doi: 10.1007/s00251-004-0756-0. Epub 
      2005 Jan 27.