PMID- 15712349
OWN - NLM
STAT- MEDLINE
DCOM- 20060516
LR  - 20221207
IS  - 1098-1004 (Electronic)
IS  - 1059-7794 (Linking)
VI  - 25
IP  - 3
DP  - 2005 Mar
TI  - Genetic polymorphisms in the transforming growth factor beta-induced gene 
      associated with BMI.
PG  - 322
AB  - In an effort to identify genetic polymorphisms in potential candidate genes for 
      type 2 diabetes mellitus (T2DM), we have sequenced the transforming growth factor 
      beta-induced gene (TGFBI), and examined the association with T2DM and diabetic 
      phenotypes in a Korean T2DM study (775 T2DM patients and 316 normal controls). 
      Twenty-eight polymorphisms were identified in TGFBI. Although no significant 
      associations were detected with the risk of T2DM, one SNP in intron 16 
      (c.2011+137C>T) and one SNP in the 3' untranslated region (UTR) (c.2589T>G), 
      showed significant association with the levels of insulin and body mass index 
      (BMI) among nondiabetic controls. The lower insulin and BMI were observed in 
      individuals who carry one or two copies of minor alleles than others. For 
      example, the highest BMI (24.21 kg/m(2)) in individuals with homozygote major 
      alleles (T) of c.2589T>G (n=99), the intermediate BMI (23.68 kg/m(2)) in 
      individuals with heterozygote alleles (n=156), and the lowest BMI (22.69 kg/m(2)) 
      in individuals with homozygote minor alleles (G) (n=57, P=0.005) were observed. 
      The present study provides, for the first time, information about genetic 
      polymorphisms in TGFBI and positive associations of those polymorphisms with 
      levels of insulin and BMI in the Korean population.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Park, Kyong Soo
AU  - Park KS
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Shin, Hyoung Doo
AU  - Shin HD
FAU - Park, Byung Lae
AU  - Park BL
FAU - Cheong, Hyun Sub
AU  - Cheong HS
FAU - Choa, Young Min
AU  - Choa YM
FAU - Lee, Hong Kyu
AU  - Lee HK
FAU - Lee, Jong-Young
AU  - Lee JY
FAU - Lee, Jong-Keuk
AU  - Lee JK
FAU - Kim, Hung Tae
AU  - Kim HT
FAU - Han, Bok Ghee
AU  - Han BG
FAU - Kim, Jun Woo
AU  - Kim JW
FAU - Koh, InSong
AU  - Koh I
FAU - Kim, Young Jin
AU  - Kim YJ
FAU - Kimm, Kuchan
AU  - Kimm K
FAU - Oh, Bermseok
AU  - Oh B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Mutat
JT  - Human mutation
JID - 9215429
RN  - 0 (3' Untranslated Regions)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Triglycerides)
RN  - 148710-76-3 (betaIG-H3 protein)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - 3' Untranslated Regions/genetics
MH  - Aged
MH  - Alleles
MH  - Amino Acid Substitution
MH  - Blood Glucose/analysis
MH  - *Body Mass Index
MH  - Cholesterol/blood
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Exons/genetics
MH  - Extracellular Matrix Proteins/*genetics/physiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/genetics
MH  - Introns/genetics
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Mutation, Missense
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Risk
MH  - Transforming Growth Factor beta/*genetics/physiology
MH  - Triglycerides/blood
MH  - Waist-Hip Ratio
EDAT- 2005/02/16 09:00
MHDA- 2006/05/17 09:00
CRDT- 2005/02/16 09:00
PHST- 2005/02/16 09:00 [pubmed]
PHST- 2006/05/17 09:00 [medline]
PHST- 2005/02/16 09:00 [entrez]
AID - 10.1002/humu.9315 [doi]
PST - ppublish
SO  - Hum Mutat. 2005 Mar;25(3):322. doi: 10.1002/humu.9315.