PMID- 15713216
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 2
DP  - 2005 Feb
TI  - HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese 
      ethnic groups.
PG  - 172-7
AB  - DPA1 gene is one of the human leukocyte antigen (HLA) class II genes and its 
      promoter is highly polymorphic. From comparative studies among five southern 
      Chinese populations, Jing, Li, Bai, Lahu, and Meizhou Han, we describe their 
      single-nucleotide polymorphism (SNP)/haplotype frequency data of HLA-DPA1 gene 
      promoter in this study. Within the 760-bp promoter region, we have identified 21 
      SNPs and nine possible haplotypes. Pair-wise comparisons show similar frequencies 
      distribution of the HLA-DPA1 promoter haplotypes among Jing, Li, and Bai, whereas 
      all pair-wise comparisons involved with Lahu or Meizhou Han and other ethnic 
      groups show remarkable difference. The differences in frequencies of HLA-DPA1 
      promoter alleles may reveal different ethnic origins and demographic histories of 
      the five populations. Our study may help distinguishing each of these populations 
      by sequence variations of HLA-DPA1 promoter, which may be served as functional 
      molecular markers for clinical and immunological studies involving the DPA1 
      locus.
FAU - Liu, X
AU  - Liu X
AD  - Key Laboratory of Genetic Engineering of MOE, Department of Biochemistry, College 
      of Life Sciences, Sun Yat-Sen (Zhongshan) University, 510275 Guangzhou, People's 
      Republic of China.
FAU - Xu, Y
AU  - Xu Y
FAU - Shen, Y
AU  - Shen Y
FAU - Zhang, H
AU  - Zhang H
FAU - Fu, Y
AU  - Fu Y
FAU - Liu, Z
AU  - Liu Z
FAU - Xu, A
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP alpha-Chains)
RN  - 0 (HLA-DPA1 antigen)
SB  - IM
MH  - Alleles
MH  - Asian People/ethnology
MH  - Ethnicity/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DP Antigens/*genetics
MH  - HLA-DP alpha-Chains
MH  - Haplotypes/*genetics
MH  - Humans
MH  - Phylogeny
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2005/02/17 09:00
MHDA- 2005/06/24 09:00
CRDT- 2005/02/17 09:00
PHST- 2005/02/17 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2005/02/17 09:00 [entrez]
AID - TAN355 [pii]
AID - 10.1111/j.1399-0039.2005.00355.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Feb;65(2):172-7. doi: 10.1111/j.1399-0039.2005.00355.x.