PMID- 15713222
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 65
IP  - 2
DP  - 2005 Feb
TI  - Human leukocyte antigen class II alleles in Caucasian women with primary biliary 
      cirrhosis.
PG  - 199-205
AB  - In the current study, we investigated human leukocyte antigen (HLA) class II 
      alleles in Caucasian women with primary biliary cirrhosis (PBC), a disease that 
      preferentially affects women. Alleles of DRB1, DQA1, and DQB1 were determined by 
      DNA-based HLA typing for women with PBC (n = 72) and healthy women (n = 381). All 
      study subjects were Caucasian. HLA DRB1*08 was significantly increased in women 
      with PBC compared to healthy women. The increase was primarily due to the 
      DRB1*0801 allele, also the most common DRB1*08 allele among controls. DQB1*04 and 
      DQA1*0401 were significantly increased. DRB1*1501, DQA1*0102, and DQB1*0602 were 
      associated with decreased risk. Analyses conducted comparing parous women with 
      PBC to parous healthy women (n = 68 and n = 282, respectively) yielded similar 
      significant results. Although the DRB1*08-DQA1*0401-DQB1*04 haplotype was 
      significantly associated with PBC, consistent with other studies, this haplotype 
      nevertheless represented only 19% (14/72) of all PBC patients and can account for 
      only a minority of the risk of PBC.
FAU - Mullarkey, M E
AU  - Mullarkey ME
AD  - Immunogenetics Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave 
      N, Seattle, WA 98109, USA.
FAU - Stevens, A M
AU  - Stevens AM
FAU - McDonnell, W M
AU  - McDonnell WM
FAU - Loubiere, L S
AU  - Loubiere LS
FAU - Brackensick, J A
AU  - Brackensick JA
FAU - Pang, J M
AU  - Pang JM
FAU - Porter, A J
AU  - Porter AJ
FAU - Galloway, D A
AU  - Galloway DA
FAU - Nelson, J L
AU  - Nelson JL
LA  - eng
GR  - AI41721/AI/NIAID NIH HHS/United States
GR  - AI45952/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Liver Cirrhosis, Biliary/*genetics/immunology
MH  - Membrane Glycoproteins/genetics
MH  - Middle Aged
MH  - Risk Factors
MH  - White People
EDAT- 2005/02/17 09:00
MHDA- 2005/06/24 09:00
CRDT- 2005/02/17 09:00
PHST- 2005/02/17 09:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2005/02/17 09:00 [entrez]
AID - TAN351 [pii]
AID - 10.1111/j.1399-0039.2005.00351.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Feb;65(2):199-205. doi: 10.1111/j.1399-0039.2005.00351.x.