PMID- 15713339
OWN - NLM
STAT- MEDLINE
DCOM- 20050503
LR  - 20081121
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 26
IP  - 2
DP  - 2005 Mar
TI  - Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural 
      profile: interference from the administration route.
PG  - 183-92
AB  - Among the most persistent and bio-accumulative environmental pollutants are the 
      polybrominated diphenyl ethers (PBDEs), a class of chemicals widely used as flame 
      retardants in plastics and textile coating, and the polychlorinated biphenyls 
      (PCBs), previously used as coolants and lubricants in electrical equipment. 
      Monitoring programs revealed high levels of both these classes of compounds in 
      human breast milk, raising concerns for their potential noxious effects on 
      infants. The aim of the present study was to investigate the neurotoxic effects 
      of 2,2',4,4',5-penta BDE (BDE 99: 18mg/kg/day) or Aroclor 1254 (A1254, a PCB 
      mixture: 10mg/kg/day) administration, from gestational day (GD) 6 to postnatal 
      day (PND) 21, on neurobehavioral development in the CD-1 Swiss mouse. In 
      addition, we investigated whether the administration route affects the emergence 
      or the magnitude of the toxic effects of BDE 99 or A1254. In particular, we 
      compared self-administration, consisting in letting the mouse drink spontaneously 
      the compound dissolved in oil from a syringe, with gavage, consisting in 
      force-feeding a substance by a tube inserted in the mouth and then into the 
      stomach, a procedure reported to be stress-inducing. Both compounds induced 
      hyperactivity, though BDE 99 affected activity profile only during adolescence 
      and A1254 mainly at adulthood. Levels of total circulating thyroxine were 
      decreased by both BDE 99 and A1254 administration, though only in the latter 
      group the decrease was statistically significant. These findings suggest a 
      different neurotoxic action exerted by PBDEs and PCBs. An effect of the 
      administration route, independent from the compound administered, was found on 
      thigmotactic behavior and gavage administration affected pup body weight gain 
      only in the A1254 group, suggesting that the stress induced by gavage procedure 
      may either affect results per se or modulate the detrimental action of selected 
      compounds.
FAU - Branchi, Igor
AU  - Branchi I
AD  - Istituto Superiore di Sanita, Section of Behavioural Neuroscience, Department of 
      Cell Biology and Neuroscience, Viale Regina Elena 299, 00161 Rome, Italy. 
      branchi@iss.it
FAU - Capone, Francesca
AU  - Capone F
FAU - Vitalone, Annabella
AU  - Vitalone A
FAU - Madia, Federica
AU  - Madia F
FAU - Santucci, Daniela
AU  - Santucci D
FAU - Alleva, Enrico
AU  - Alleva E
FAU - Costa, Lucio G
AU  - Costa LG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (2,2',4,4',5-brominated diphenyl ether)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Phenyl Ethers)
RN  - 11097-69-1 (Chlorodiphenyl (54% Chlorine))
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Brain/drug effects/growth & development
MH  - Chlorodiphenyl (54% Chlorine)/*administration & dosage
MH  - Female
MH  - Halogenated Diphenyl Ethers
MH  - Intubation, Gastrointestinal
MH  - Male
MH  - Mice
MH  - Motor Activity/*drug effects/physiology
MH  - Phenyl Ethers/*administration & dosage
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Self Administration
EDAT- 2005/02/17 09:00
MHDA- 2005/05/04 09:00
CRDT- 2005/02/17 09:00
PHST- 2004/05/24 00:00 [received]
PHST- 2004/11/23 00:00 [accepted]
PHST- 2005/02/17 09:00 [pubmed]
PHST- 2005/05/04 09:00 [medline]
PHST- 2005/02/17 09:00 [entrez]
AID - S0161-813X(04)00163-9 [pii]
AID - 10.1016/j.neuro.2004.11.005 [doi]
PST - ppublish
SO  - Neurotoxicology. 2005 Mar;26(2):183-92. doi: 10.1016/j.neuro.2004.11.005.