PMID- 15714057
OWN - NLM
STAT- MEDLINE
DCOM- 20050630
LR  - 20220409
IS  - 1052-9551 (Print)
IS  - 1052-9551 (Linking)
VI  - 14
IP  - 1
DP  - 2005 Mar
TI  - Molecular diagnostic techniques for the clinical evaluation of gliomas.
PG  - 1-8
AB  - Newly developed molecular techniques have been integrated into the routine 
      assessment of gliomas in some laboratories. These tests serve to complement the 
      subjective nature of morphologic analysis. Such strategies add useful information 
      regarding pathogenicity, patient survival, and potential response to treatment. 
      As we learn more about the molecular characteristics of these tumors, this 
      information will provide the basis for the development of specific, targeted 
      therapies. This review will describe the background, methods, clinical utility, 
      and strengths and weaknesses of several molecular approaches, including 
      fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), loss of 
      heterozygosity (LOH)-testing, and nucleic acid sequencing, that are currently 
      being employed in the diagnosis and evaluation of glial tumors.
FAU - Kelley, Todd W
AU  - Kelley TW
AD  - Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 
      44195, USA.
FAU - Tubbs, Raymond R
AU  - Tubbs RR
FAU - Prayson, Richard A
AU  - Prayson RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Diagn Mol Pathol
JT  - Diagnostic molecular pathology : the American journal of surgical pathology, part 
      B
JID - 9204924
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 3.1.3.2 (Phosphoric Monoester Hydrolases)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Base Sequence
MH  - Brain Neoplasms/*diagnosis/*genetics
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 19/genetics
MH  - DNA, Neoplasm/genetics
MH  - ErbB Receptors/genetics
MH  - Genes, Neurofibromatosis 1
MH  - Genes, Neurofibromatosis 2
MH  - Genes, p53
MH  - Glioma/*diagnosis/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Mutation
MH  - PTEN Phosphohydrolase
MH  - Phosphoric Monoester Hydrolases/genetics
MH  - Tumor Suppressor Proteins/genetics
RF  - 69
EDAT- 2005/02/17 09:00
MHDA- 2005/07/01 09:00
CRDT- 2005/02/17 09:00
PHST- 2005/02/17 09:00 [pubmed]
PHST- 2005/07/01 09:00 [medline]
PHST- 2005/02/17 09:00 [entrez]
AID - 00019606-200503000-00001 [pii]
AID - 10.1097/01.pdm.0000138207.96718.85 [doi]
PST - ppublish
SO  - Diagn Mol Pathol. 2005 Mar;14(1):1-8. doi: 10.1097/01.pdm.0000138207.96718.85.