PMID- 15714173
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20190713
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 79
IP  - 1
DP  - 2005 Jan 15
TI  - Simultaneous development of lymphoma in recipients of renal transplants from a 
      single donor: donor origin confirmed by human leukocyte antigen staining and 
      microsatellite analysis.
PG  - 79-84
AB  - BACKGROUND: Posttransplant lymphoproliferative disorders (PTLD) occur in 0.5% to 
      2.5% of cases in renal-transplant recipients. Epstein-Barr virus (EBV) is usually 
      detected in the tumor cells, suggesting a role for this virus as an agent of 
      B-cell proliferation. It is unusual for patients receiving allografts from the 
      same donor to develop PTLD simultaneously. METHODS: we describe two patients who 
      received renal allografts from the same donor and developed PTLD simultaneously. 
      The presence of EBV in both tumors was confirmed. In this report, the origin of 
      tumor cells was determined by immunohistochemical human leukocyte antigen (HLA) 
      typing and microsatellite analysis. Clonality was studied by immunoglobulin gene 
      rearrangement analysis. RESULTS: Our results suggest that the tumor originated 
      from donor cells in both patients but, because immunoglobulin gene rearrangements 
      were different, this could mean that lymphoid cells proliferate independently in 
      each recipient. CONCLUSIONS: We propose the following pathogenesis: 
      immortalization of passenger B lymphocytes by EBV, proliferation of these cells, 
      and development of PTLD by means of immunosuppression, antigenic stimulation, and 
      HLA mismatch.
FAU - Caillard, Sophie
AU  - Caillard S
AD  - Department of Nephrology and Transplantation, Hopitaux Universitaires de 
      Strasbourg, France. sophie.caillard@chru-strasbourg.fr
FAU - Pencreach, Erwan
AU  - Pencreach E
FAU - Braun, Laura
AU  - Braun L
FAU - Marcellin, Luc
AU  - Marcellin L
FAU - Jaegle, Marie-Lorraine Woehl
AU  - Jaegle ML
FAU - Wolf, Philippe
AU  - Wolf P
FAU - Parissiadis, Anne
AU  - Parissiadis A
FAU - Hannedouche, Thierry
AU  - Hannedouche T
FAU - Gaub, Marie-Pierre
AU  - Gaub MP
FAU - Moulin, Bruno
AU  - Moulin B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gene Rearrangement
MH  - Genes, Immunoglobulin
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney Transplantation/*adverse effects
MH  - Lymphoma/*etiology
MH  - Male
MH  - *Microsatellite Repeats
MH  - Middle Aged
MH  - *Tissue Donors
EDAT- 2005/02/17 09:00
MHDA- 2005/03/04 09:00
CRDT- 2005/02/17 09:00
PHST- 2005/02/17 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2005/02/17 09:00 [entrez]
AID - 00007890-200501150-00013 [pii]
AID - 10.1097/01.tp.0000146385.40108.2b [doi]
PST - ppublish
SO  - Transplantation. 2005 Jan 15;79(1):79-84. doi: 10.1097/01.tp.0000146385.40108.2b.