PMID- 15715083
OWN - NLM
STAT- MEDLINE
DCOM- 20050303
LR  - 20190513
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 64
IP  - 1
DP  - 2005 Jan
TI  - Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal 
      regeneration and functional recovery after complete transection of adult rat 
      spinal cord.
PG  - 37-45
AB  - The aim of this study was to evaluate whether transplantation of Schwann cells 
      derived from bone marrow stromal cells (BMSC-SCs) promotes axonal regeneration 
      and functional recovery in completely transected spinal cord in adult rats. Bone 
      marrow stromal cells (BMSCs) were induced to differentiate into Schwann cells in 
      vitro. A 4-mm segment of rat spinal cord was removed completely at the T7 level. 
      An ultra-filtration membrane tube, filled with a mixture of Matrigel (MG) and 
      BMSC-SCs (BMSC-SC group) or Matrigel alone (MG group), was grafted into the gap. 
      In the BMSC-SC group, the number of neurofilament- and tyrosine 
      hydroxylase-immunoreactive nerve fibers was significantly higher compared to the 
      MG group, although 5-hydroxytryptamine- or calcitonin gene-related 
      peptide-immunoreactive fibers were rarely detectable in both groups. In the 
      BMSC-SC group, significant recovery of the hindlimb function was recognized, 
      which was abolished by retransection of the graft 6 weeks after transplantation. 
      These results demonstrate that transplantation of BMSC-SCs promotes axonal 
      regeneration of lesioned spinal cord, resulting in recovery of hindlimb function 
      in rats. Transplantation of BMSC-SCs is a potentially useful treatment for spinal 
      cord injury.
FAU - Kamada, Takahito
AU  - Kamada T
AD  - Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine, 
      1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan.
FAU - Koda, Masao
AU  - Koda M
FAU - Dezawa, Mari
AU  - Dezawa M
FAU - Yoshinaga, Katsunori
AU  - Yoshinaga K
FAU - Hashimoto, Masayuki
AU  - Hashimoto M
FAU - Koshizuka, Shuhei
AU  - Koshizuka S
FAU - Nishio, Yutaka
AU  - Nishio Y
FAU - Moriya, Hideshige
AU  - Moriya H
FAU - Yamazaki, Masashi
AU  - Yamazaki M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
SB  - IM
MH  - Animals
MH  - Axons/*transplantation
MH  - Bone Marrow Transplantation/*methods
MH  - Immunohistochemistry
MH  - Male
MH  - Motor Activity/physiology
MH  - Nerve Regeneration/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/*physiology
MH  - Schwann Cells/cytology/*transplantation
MH  - Spinal Cord Injuries/metabolism/pathology/*physiopathology
MH  - Stromal Cells/cytology/transplantation
MH  - Thoracic Vertebrae/innervation/surgery
MH  - Time Factors
EDAT- 2005/02/18 09:00
MHDA- 2005/03/04 09:00
CRDT- 2005/02/18 09:00
PHST- 2005/02/18 09:00 [pubmed]
PHST- 2005/03/04 09:00 [medline]
PHST- 2005/02/18 09:00 [entrez]
AID - 10.1093/jnen/64.1.37 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2005 Jan;64(1):37-45. doi: 10.1093/jnen/64.1.37.