PMID- 15719608
OWN - NLM
STAT- MEDLINE
DCOM- 20050318
LR  - 20161021
IS  - 1110-4902 (Print)
VI  - 10
IP  - 2
DP  - 2003
TI  - Proinflammatory cytokines (IL-12 and IL-18) in immune rheumatic diseases: 
      relation with disease activity and autoantibodies production.
PG  - 19-26
AB  - Interleukin-18 (IL-18) and its inducer IL-12 have multiple biological activities 
      that are important in generating Th1 responses and inflammatory tissue damage. We 
      investigated serum concentration of the novel proinflammatory Th1 cytokine; 
      IL-18, and its inducer IL-12 in patients with immune rheumatic diseases. Group I 
      comprised32 patients of systemic lupus erythmatosus (SLE), Group II comprised 36 
      patients of rheumatoid arthritis (RA). Group III comprised 9 patients (2 patients 
      of Behcet, 2 patients of Dermatomyositis, 2 patients of Sicca syndrome, one 
      patient of Scleroderma, and 2 patients of Mixed connective tissue disease). Group 
      IV is a control group consists of 21 sex and age matched healthy subjects and 
      correlated their levels with autoantibody concentration (ANA and ds-DNA), 
      clinical grades and SLE disease activity index (SLEDAI). Serum IL-18, IL-12, ANA 
      and ds-DNA were measured by enzyme immuno sorbent assay. IL-18, IL-12 and ANA 
      were significantly higher in the three studied groups than in the control group 
      (IL-18; P < 0.001 in the three groups, IL-12; P = 0.019, P = 0.002, and P = 
      0.006, and ANA; P < 0.001, P = 0.002,and P = 0.006, respectively).ds-DNA was 
      significantly higher in SLE patients than in control group (P < 0.001). There 
      were significant positive correlations between; A) levels of IL-18,and both ANA 
      and ds-DNA in SLE patient (r = 0.41,P = 0.001, r = 0.58 and P=0.001 
      respectively); and B) IL-18 and ANA in both RA and group III patients (r = 0.32, 
      P = 0.005, r = 0.61and P = 0.022 respectively). Also, there were significant 
      positive correlation between the levels of IL-18 and clinical grades of the three 
      groups (r = 0.60,P = 0.001, r = 0.79,P = 0.001, r = 0.78 and P= 0.001 
      respectively). In SLE patients , IL-18 concentration shows significant positive 
      correlation with SLEDAI score (r = 0.76, P = 0.001). In conclusion, the elevation 
      of proinflammatory cytokines (IL-18 and IL-12 ) may trigger the inflammatory 
      process in immune rheumatic diseases and IL-18 is correlated with disease 
      activity
FAU - Mosaad, Youssef M
AU  - Mosaad YM
AD  - Clinical Immunology Unit, Clinical Pathology Department, Mansoura Faculty of 
      Medicine, Mansoura University, Mansoura, Egypt.
FAU - Metwally, Shereen S
AU  - Metwally SS
FAU - Auf, Fatma A
AU  - Auf FA
FAU - AbdEL-Samee, Elham R
AU  - AbdEL-Samee ER
FAU - el-Deek, Basem
AU  - el-Deek B
FAU - Limon, Nabil I
AU  - Limon NI
FAU - el-Chennawi, Farha A
AU  - el-Chennawi FA
LA  - eng
PT  - Journal Article
PL  - Egypt
TA  - Egypt J Immunol
JT  - The Egyptian journal of immunology
JID - 9816016
RN  - 0 (Autoantibodies)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-18)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Arthritis, Rheumatoid/immunology
MH  - Autoantibodies/*biosynthesis
MH  - Behcet Syndrome/immunology
MH  - Dermatomyositis/immunology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Interleukin-12/*blood
MH  - Interleukin-18/*blood
MH  - Lupus Erythematosus, Systemic/immunology
MH  - Male
MH  - Mixed Connective Tissue Disease/immunology
MH  - Rheumatic Diseases/*immunology
MH  - Sjogren's Syndrome/immunology
EDAT- 2005/02/22 09:00
MHDA- 2005/03/19 09:00
CRDT- 2005/02/22 09:00
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/03/19 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
PST - ppublish
SO  - Egypt J Immunol. 2003;10(2):19-26.