PMID- 15720934
OWN - NLM
STAT- MEDLINE
DCOM- 20050609
LR  - 20220331
IS  - 0960-1643 (Print)
IS  - 0960-1643 (Linking)
VI  - 55
IP  - 511
DP  - 2005 Feb
TI  - Accuracy of specific IgE in the prediction of asthma: development of a scoring 
      formula for general practice.
PG  - 125-31
AB  - BACKGROUND: For the diagnosis of asthma in young children, GPs have to rely on 
      history taking and physical examination, as spirometry is not possible. The 
      additional diagnostic value of specific immunoglobulin E (IgE) to inhalent 
      allergens remains unclear. AIM: To assess the predictive accuracy of specific IgE 
      to cat, dog, and/or house dust mites in young children for the subsequent 
      development of asthma at the age of 6 years. DESIGN OF STUDY: Prospective 
      follow-up study. SETTING: Seventy-two general practices. METHOD: A total of 654 
      children, aged 1-4 years, visiting their GPs for persistent coughing (>/= 5 
      days), were tested for IgE antibodies by radio allergosorbent testing (RAST). 
      Parents completed a questionnaire on potential risk indicators. Those children 
      who showed an IgE-positive status (12.7%) and a random sample of those with an 
      IgE-negative status (<0.5 U/ml) were followed up to the age of 6 years when the 
      asthma status was established. The main outcome measure was asthma at the age of 
      6 years (combination of both symptoms and/or use of asthma medication, and 
      impaired lung function). RESULTS: Addition of RAST results to a prediction model 
      based on age, wheeze, and family history of pollen allergy increased the area 
      under the receiver operating characteristic (ROC) curve from 0.76 to 0.87. 
      Furthermore, RAST improved patient differentiation as indicated by a change in 
      the range of asthma probabilities from 6-75% before the IgE test, to 1-95% after 
      the IgE-test. CONCLUSION: Sensitisation to inhalant allergens in 1-4-year-olds, 
      as shown by RAST, is a useful diagnostic indicator for the presence of asthma at 
      the age of 6 years, even after a clinical history has been obtained. This model 
      should preferably be validated in a new population before it can be applied in 
      practice.
FAU - Eysink, Petra E D
AU  - Eysink PE
AD  - Department of General Practice, Academic Medical Center, University of Amsterdam, 
      Amsterdam, The Netherlands.
FAU - ter Riet, Gerben
AU  - ter Riet G
FAU - Aalberse, Rob C
AU  - Aalberse RC
FAU - van Aalderen, Wim M C
AU  - van Aalderen WM
FAU - Roos, Carel M
AU  - Roos CM
FAU - van der Zee, Jaring S
AU  - van der Zee JS
FAU - Bindels, Patrick J E
AU  - Bindels PJ
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Gen Pract
JT  - The British journal of general practice : the journal of the Royal College of 
      General Practitioners
JID - 9005323
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*adverse effects
MH  - Animals
MH  - Asthma/diagnosis/*immunology
MH  - Biomarkers/blood
MH  - Cats/immunology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dogs/immunology
MH  - Dust/immunology
MH  - Family Practice
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Male
MH  - Mites/immunology
MH  - Predictive Value of Tests
MH  - Prospective Studies
PMC - PMC1463187
EDAT- 2005/02/22 09:00
MHDA- 2005/06/10 09:00
PMCR- 2006/02/01
CRDT- 2005/02/22 09:00
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/06/10 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
PHST- 2006/02/01 00:00 [pmc-release]
PST - ppublish
SO  - Br J Gen Pract. 2005 Feb;55(511):125-31.