PMID- 15721079
OWN - NLM
STAT- MEDLINE
DCOM- 20050527
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 116
IP  - 3
DP  - 2005 Mar
TI  - Developmental changes in refractoriness of the cortical auditory evoked 
      potential.
PG  - 648-57
AB  - OBJECTIVE: This study examined morphological changes in the cortical auditory 
      evoked potential (CAEP) waveform as a function of varying stimulation rate. 
      Stimuli were presented in a paradigm which indirectly assesses the refractory 
      properties of the underlying neuronal generators. METHODS: CAEPs were recorded in 
      50 normal-hearing children (3-12 years) and 10 young adults (24-26 years). A 
      speech sound was presented in a stimulus train with sequentially decreasing 
      inter-stimulus intervals (ISIs) of 2000, 1000, 560, and 360ms. Latencies and 
      amplitudes of the P1, N1, and P2 components at the Cz electrode were examined as 
      a function of stimulus rate and age. RESULTS: Results revealed significant 
      changes in the CAEP as a function of age and stimulation rate. At younger ages 
      the N1-P2 component was elicited only at the slowest stimulation rates, and was 
      more clearly apparent at successively faster stimulation rates as age increased. 
      CONCLUSIONS: We have described a stimulus paradigm that allows examination of the 
      development of refractoriness by highlighting the interaction between age and 
      rate on CAEP morphology. SIGNIFICANCE: Complex maturational patterns of CAEP 
      components are best understood when the effects of both age and stimulus rate on 
      the CAEP waveform are considered.
FAU - Gilley, Phillip M
AU  - Gilley PM
AD  - Callier Advanced Hearing Research Center, School of Behavioral and Brain 
      Sciences, University of Texas at Dallas, 1966 Inwood Road, Dallas, TX 75235, USA. 
      pgilley@utdallas.edu
FAU - Sharma, Anu
AU  - Sharma A
FAU - Dorman, Michael
AU  - Dorman M
FAU - Martin, Kathryn
AU  - Martin K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adult
MH  - Age Factors
MH  - Aging/*physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/anatomy & histology/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Electrodes
MH  - Electroencephalography/methods
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Neuronal Plasticity/*physiology
MH  - Reaction Time/physiology/radiation effects
MH  - Speech Perception/*physiology
MH  - Time Factors
EDAT- 2005/02/22 09:00
MHDA- 2005/05/28 09:00
CRDT- 2005/02/22 09:00
PHST- 2004/09/16 00:00 [accepted]
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/05/28 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
AID - S1388-2457(04)00367-0 [pii]
AID - 10.1016/j.clinph.2004.09.009 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2005 Mar;116(3):648-57. doi: 10.1016/j.clinph.2004.09.009.