PMID- 15721082
OWN - NLM
STAT- MEDLINE
DCOM- 20050527
LR  - 20080910
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 116
IP  - 3
DP  - 2005 Mar
TI  - The P50 midlatency auditory evoked potential in patients with chronic low back 
      pain (CLBP).
PG  - 681-9
AB  - OBJECTIVE: Patients with Chronic Low Back Pain (CLBP) show arousal, attentional 
      and cognitive disturbances. The sleep state-dependent P50 midlatency auditory 
      evoked potential was used to determine if patients with CLBP [with and without 
      co-morbid depression (DEP)] show quantitative disturbances in the manifestation 
      of the P50 potential. METHODS: P50 potential latency, amplitude and habituation 
      to repetitive stimuli at 250, 500 and 1000ms interstimulus intervals (ISIs) was 
      recorded, along with the McGill Pain Questionnaire-Short Form (MPQ-SF). CLBP 
      subjects (n=42) were compared with Controls (n=43), and with subjects with DEP 
      only (n=6). Of the CLBP subjects, 20/42 had clinical depression (CLBP+DEP); 8/20 
      were taking anti-depressant medication (CLBP+DEP+med), the others were not 
      (CLBP+DEP-med). RESULTS: There were no differences (ANOVA) in age, sex or P50 
      potential latency, although there was a trend towards increased latencies in CLBP 
      groups. P50 potential amplitude was lower in CLBP groups, but not in sub-groups, 
      again indicating a trend. P50 potential habituation was decreased in the DEP only 
      subjects at the 250m ISI, and decreased in CLBP+DEP-med subjects at the 500ms 
      ISI. This difference was not present in CLBP+DEP+med subjects. The MPQ-SF 
      revealed that patients with CLBP and CLBP+DEP-med showed lower pain scores than 
      CLBP+DEP+med patients. CONCLUSIONS: There is decreased habituation of the P50 
      potential habituation in unmedicated patients with CLBP+DEP compared to Controls. 
      SIGNIFICANCE: Patients with CLBP+DEP-med may be less able to disregard incoming 
      sensory information, including painful sensations, but anti-depressant 
      medications help correct this deficit. However, their perception of pain may be 
      increased by medication.
FAU - Fann, A V
AU  - Fann AV
AD  - Department of Physical Medicine and Rehabilitation, Central Arkansas Veterans 
      Healthcare System, 2200 Fort Roots Dr, North Little Rock, AR 72114, USA. 
      fannalicev@uams.edu
FAU - Preston, M A
AU  - Preston MA
FAU - Bray, P
AU  - Bray P
FAU - Mamiya, N
AU  - Mamiya N
FAU - Williams, D K
AU  - Williams DK
FAU - Skinner, R D
AU  - Skinner RD
FAU - Garcia-Rill, E
AU  - Garcia-Rill E
LA  - eng
GR  - RR020146/RR/NCRR NIH HHS/United States
GR  - RR14288/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20041123
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Adult
MH  - Analysis of Variance
MH  - Antidepressive Agents/therapeutic use
MH  - Auditory Perception/drug effects/*physiology
MH  - Chronic Disease
MH  - Depression/drug therapy/etiology
MH  - Dose-Response Relationship, Radiation
MH  - Electroencephalography/methods
MH  - Evoked Potentials, Auditory/drug effects/*physiology
MH  - Female
MH  - Habituation, Psychophysiologic
MH  - Humans
MH  - Low Back Pain/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Reaction Time/drug effects/*physiology
MH  - Time Factors
MH  - Veterans
EDAT- 2005/02/22 09:00
MHDA- 2005/05/28 09:00
CRDT- 2005/02/22 09:00
PHST- 2004/06/15 00:00 [received]
PHST- 2004/08/23 00:00 [revised]
PHST- 2004/09/30 00:00 [accepted]
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/05/28 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
AID - S1388-2457(04)00387-6 [pii]
AID - 10.1016/j.clinph.2004.09.026 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2005 Mar;116(3):681-9. doi: 10.1016/j.clinph.2004.09.026. Epub 
      2004 Nov 23.