PMID- 15721508
OWN - NLM
STAT- MEDLINE
DCOM- 20051017
LR  - 20171116
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 99
IP  - 1
DP  - 2005 Mar 10
TI  - Left atrial function, cytokines and soluble apoptotic markers in mitral stenosis: 
      effects of valvular replacement.
PG  - 111-5
AB  - BACKGROUND: Patients with mitral stenosis (MS) and heart failure (HF) are 
      characterized by changes in the left atrial (LA) function and activation of the 
      apoptotic process. The purpose of the present study was the evaluation of the 
      effect of mitral valve replacement on the LA function, on inflammatory process 
      and apoptotic markers in patients with MS and HF. METHODS: We studied 30 patients 
      with MS and HF (15 in NYHA III-IV and 15 in NYHA IV) in sinus rhythm (mean age 
      56.2 +/- 4.6 years), and 20 age and gender matched healthy volunteers. Blood 
      samples were obtained before and 6 months after surgical mitral valve 
      replacement, and plasma levels of soluble Fas/APO-1 receptor (sFas), tumor 
      necrosis factor-alpha (TNF-a) and interleukin-6 (IL-6) were measured. 
      Echocardiographically, LA volumes were measured at mitral valve opening (Vmax), 
      at the onset of left atrial systole (P wave of the electrocardiogram, Vp) and at 
      the mitral valve closure (Vmin). LA contractile function was assessed by the LA 
      active emptying fraction (ACTEF). RESULTS: After mitral valve replacement, TNF-a, 
      IL-6 and sFas levels, as well as the Vmax LA volume, were significantly reduced 
      (p < 0.05). ACTEF showed a significant postoperative decrease (0.29 +/- 0.09 vs. 
      0.23 +/- 0.06, p < 0.01) and it was significantly correlated with sFas (r = 
      -0.88, p = 0.001), TNF-a (r = -0.81, p = 0.001) and IL-6 (r = -0.74, p = 0.001) 
      levels. CONCLUSION: The present findings indicate that mitral valve replacement 
      in patients with mitral valve stenosis, reduces the size of the left atrium, 
      improves left atrial contractile function and depresses inflammatory and 
      apoptotic process.
FAU - Trikas, Athanasios
AU  - Trikas A
AD  - Cardiology Department, University of Athens, Hippokration Hospital, Greece. 
      atrikas@otenet.gr
FAU - Papathanasiou, Sotirios
AU  - Papathanasiou S
FAU - Tousoulis, Dimitris
AU  - Tousoulis D
FAU - Tentolouris, Konstantinos
AU  - Tentolouris K
FAU - Vasiliadou, Karmen
AU  - Vasiliadou K
FAU - Antoniades, Charalambos
AU  - Antoniades C
FAU - Latsios, Georgios
AU  - Latsios G
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Apoptosis
MH  - Biomarkers/blood
MH  - Heart Atria/physiopathology
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Middle Aged
MH  - Mitral Valve Stenosis/*blood/pathology/*physiopathology/surgery
MH  - Tumor Necrosis Factor-alpha/*analysis
MH  - fas Receptor/*blood
EDAT- 2005/02/22 09:00
MHDA- 2005/10/18 09:00
CRDT- 2005/02/22 09:00
PHST- 2003/08/22 00:00 [received]
PHST- 2004/01/08 00:00 [revised]
PHST- 2004/01/08 00:00 [accepted]
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/10/18 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
AID - S0167527304002165 [pii]
AID - 10.1016/j.ijcard.2004.01.018 [doi]
PST - ppublish
SO  - Int J Cardiol. 2005 Mar 10;99(1):111-5. doi: 10.1016/j.ijcard.2004.01.018.