PMID- 15722131
OWN - NLM
STAT- MEDLINE
DCOM- 20050804
LR  - 20181201
IS  - 0142-9612 (Print)
IS  - 0142-9612 (Linking)
VI  - 26
IP  - 22
DP  - 2005 Aug
TI  - In vivo degradation of porous poly(propylene fumarate)/poly(DL-lactic-co-glycolic 
      acid) composite scaffolds.
PG  - 4616-23
AB  - This study investigated the in vivo degradation of poly(propylene fumarate) 
      (PPF)/poly(DL-lactic-co-glycolic acid) (PLGA) composite scaffolds designed for 
      controlled release of osteogenic factors. PPF/PLGA composites were implanted into 
      15.0mm segmental defects in the rabbit radius, harvested after 12 and 18 weeks, 
      and analyzed using histological techniques to assess the extent of polymer 
      degradation as well as the tissue response within the pores of the scaffolds. 
      Polymer degradation was limited to micro-fragmentation of the scaffold at the 
      ends and edges of the implant at both 12 and 18 weeks. The tissue within the 
      pores of the scaffold consisted of fibrous tissue, blood vessels and some 
      inflammatory cells. In areas where polymer breakdown was evident, an increased 
      inflammatory response was observed. In contrast, areas of bone ingrowth into the 
      polymer scaffold were characterized by minimal inflammatory response and polymer 
      degradation. Our results show that minimal degradation of porous PPF occurs 
      within 18 weeks of implantation in a rabbit model. Further, the in vivo 
      degradation data of porous PPF/PLGA scaffolds are comparable with earlier 
      obtained in vitro data.
FAU - Hedberg, Elizabeth L
AU  - Hedberg EL
AD  - Department of Bioengineering, Rice University, P.O. Box 1892-MS 142, Houston, TX 
      77251-1892, USA.
FAU - Kroese-Deutman, Henriette C
AU  - Kroese-Deutman HC
FAU - Shih, Charles K
AU  - Shih CK
FAU - Crowther, Roger S
AU  - Crowther RS
FAU - Carney, Darrell H
AU  - Carney DH
FAU - Mikos, Antonios G
AU  - Mikos AG
FAU - Jansen, John A
AU  - Jansen JA
LA  - eng
GR  - R01-AR42639/AR/NIAMS NIH HHS/United States
GR  - R01-DE15164/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050118
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Fumarates)
RN  - 0 (Polymers)
RN  - 0 (Polypropylenes)
RN  - 0 (poly(propylene fumarate))
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Animals
MH  - Biodegradation, Environmental
MH  - Fumarates/*chemistry
MH  - Lactic Acid/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Polypropylenes/*chemistry
MH  - Rabbits
MH  - Radius
EDAT- 2005/02/22 09:00
MHDA- 2005/08/05 09:00
CRDT- 2005/02/22 09:00
PHST- 2004/08/24 00:00 [received]
PHST- 2004/11/30 00:00 [accepted]
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/08/05 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
AID - S0142-9612(04)01040-3 [pii]
AID - 10.1016/j.biomaterials.2004.11.039 [doi]
PST - ppublish
SO  - Biomaterials. 2005 Aug;26(22):4616-23. doi: 10.1016/j.biomaterials.2004.11.039. 
      Epub 2005 Jan 18.