PMID- 15723071
OWN - NLM
STAT- MEDLINE
DCOM- 20050511
LR  - 20210102
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 11
IP  - 3
DP  - 2005 Mar
TI  - Contribution of bone marrow-derived endothelial cells to human tumor vasculature.
PG  - 261-2
AB  - It has been shown that bone marrow-derived stem cells can form a major fraction 
      of the tumor endothelium in mouse tumors. To determine the role of such cells in 
      human tumor angiogenesis, we studied six individuals who developed cancers after 
      bone marrow transplantation with donor cells derived from individuals of the 
      opposite sex. By performing fluorescence in situ hybridization (FISH) with sex 
      chromosome-specific probes in conjunction with fluorescent antibody staining, we 
      found that such stem cells indeed contributed to tumor endothelium, but at low 
      levels, averaging only 4.9% of the total. These results illustrate substantial 
      differences between human tumors and many mouse models with respect to 
      angiogenesis and have important implications for the translation of experimental 
      antiangiogenic therapies to the clinic.
FAU - Peters, Brock A
AU  - Peters BA
AD  - The Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical 
      Institute, Johns Hopkins University School of Medicine, 1650 Orleans Street, 
      Baltimore, Maryland 21231, USA.
FAU - Diaz, Luis A
AU  - Diaz LA
FAU - Polyak, Kornelia
AU  - Polyak K
FAU - Meszler, Leslie
AU  - Meszler L
FAU - Romans, Kathy
AU  - Romans K
FAU - Guinan, Eva C
AU  - Guinan EC
FAU - Antin, Joseph H
AU  - Antin JH
FAU - Myerson, David
AU  - Myerson D
FAU - Hamilton, Stanley R
AU  - Hamilton SR
FAU - Vogelstein, Bert
AU  - Vogelstein B
FAU - Kinzler, Kenneth W
AU  - Kinzler KW
FAU - Lengauer, Christoph
AU  - Lengauer C
LA  - eng
GR  - CA57345/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050220
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
SB  - IM
MH  - Bone Marrow Cells/*cytology
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Chromosomes, Human, X
MH  - Chromosomes, Human, Y
MH  - Endothelial Cells/*cytology/physiology
MH  - Female
MH  - Fluorescent Antibody Technique
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasms/*blood supply/pathology
MH  - *Neovascularization, Pathologic/blood
MH  - Stem Cells/*physiology
EDAT- 2005/02/22 09:00
MHDA- 2005/05/12 09:00
CRDT- 2005/02/22 09:00
PHST- 2004/09/27 00:00 [received]
PHST- 2005/02/01 00:00 [accepted]
PHST- 2005/02/22 09:00 [pubmed]
PHST- 2005/05/12 09:00 [medline]
PHST- 2005/02/22 09:00 [entrez]
AID - nm1200 [pii]
AID - 10.1038/nm1200 [doi]
PST - ppublish
SO  - Nat Med. 2005 Mar;11(3):261-2. doi: 10.1038/nm1200. Epub 2005 Feb 20.