PMID- 15725427
OWN - NLM
STAT- MEDLINE
DCOM- 20050718
LR  - 20050223
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 39
IP  - 3
DP  - 2005 May
TI  - White matter hyperintensities and chronicity of depression.
PG  - 285-93
AB  - OBJECTIVE: White matter hyperintensities (WMHs) on T(2)-weighted magnetic 
      resonance imaging (MRI) of the brain are associated with advanced age and 
      late-life depression. Most investigations predominantly found these lesions in 
      frontal lobe and basal ganglia supporting the hypothesis of a fronto-striatal 
      dysfunction in depression. A prospective study was undertaken to investigate the 
      association between extent of WMHs and clinical outcome in elderly depressed 
      patients. METHODS: Thirty-one non-demented depressed subjects underwent a 1.5 T 
      cranial MRI scan. The MRI scans were analysed in consensus by two experienced 
      radiologists. Each MRI scan was assessed for presence and extent of WMHs, which 
      are differentiated in periventricular hyperintensities (PVHs) and deep white 
      matter hyperintensities (DWMHs). A total of 21 patients of the original cohort of 
      31 patients were re-assessed 5 years after baseline assessment. We ascertained 
      the severity of depressive symptoms, the longitudinal course of depression, the 
      cognitive decline and the global assessment of functioning at follow-up visit. 
      RESULTS: (1) Subjects with greater extent of WMHs had a significant higher 
      Hamilton Depression Rating Scale (HAM-D) score, (2) had more severe longitudinal 
      courses of depression (3) and had a lower Mini-Mental State Examination (MMSE) 
      score. CONCLUSIONS: WMHs on MRI are associated with poorer outcome in elderly 
      depressed subjects. Further studies are needed to evaluate WHMs as prognostic 
      factor for an appropriate treatment decision-making.
FAU - Heiden, Angela
AU  - Heiden A
AD  - Department of General Psychiatry, Medical University of Vienna, Wahringer Gurtel 
      18-20, A-1090 Vienna, Austria. angela.heiden@akh-wien.ac.at
FAU - Kettenbach, Joachim
AU  - Kettenbach J
FAU - Fischer, Peter
AU  - Fischer P
FAU - Schein, Bettina
AU  - Schein B
FAU - Ba-Ssalamah, Ahmed
AU  - Ba-Ssalamah A
FAU - Frey, Richard
AU  - Frey R
FAU - Naderi, Mohammad Mehdi
AU  - Naderi MM
FAU - Gulesserian, Talin
AU  - Gulesserian T
FAU - Schmid, Daniela
AU  - Schmid D
FAU - Trattnig, Siegfried
AU  - Trattnig S
FAU - Imhof, Herwig
AU  - Imhof H
FAU - Kasper, Siegfried
AU  - Kasper S
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Aged
MH  - Basal Ganglia/pathology/physiopathology
MH  - Brain/*pathology/*physiopathology
MH  - Cerebral Ventricles/pathology/physiopathology
MH  - Chronic Disease
MH  - Corpus Striatum/pathology/physiopathology
MH  - Decision Making
MH  - Depressive Disorder, Major/*pathology/*physiopathology
MH  - Female
MH  - Frontal Lobe/pathology/physiopathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prospective Studies
MH  - Severity of Illness Index
EDAT- 2005/02/24 09:00
MHDA- 2005/07/19 09:00
CRDT- 2005/02/24 09:00
PHST- 2004/02/22 00:00 [received]
PHST- 2004/06/19 00:00 [revised]
PHST- 2004/07/26 00:00 [accepted]
PHST- 2005/02/24 09:00 [pubmed]
PHST- 2005/07/19 09:00 [medline]
PHST- 2005/02/24 09:00 [entrez]
AID - S0022-3956(04)00088-3 [pii]
AID - 10.1016/j.jpsychires.2004.07.004 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2005 May;39(3):285-93. doi: 10.1016/j.jpsychires.2004.07.004.