PMID- 15726244
OWN - NLM
STAT- MEDLINE
DCOM- 20050524
LR  - 20181113
IS  - 0003-2417 (Print)
IS  - 0003-2417 (Linking)
VI  - 54
IP  - 4
DP  - 2005 Apr
TI  - [Extended hemodynamic monitoring using transpulmonary thermodilution Influence of 
      various factors on the accuracy of the estimation of intrathoracic blood volume 
      and extravascular lung water in critically ill patients].
PG  - 319-26
AB  - BACKGROUND: The transpulmonary thermal-dye dilution (TDD) is the clinical gold 
      standard for measurement of intrathoracic blood volume (ITBV) and extravascular 
      lung water (EVLW). Recently, experimental and clinical studies found that ITBV 
      and EVLW can be derived reliably by single transpulmonary thermodilution (TD), 
      however, dependency from various factors of lung function has been discussed. 
      PATIENTS AND METHODS: We retrospectively analyzed data from 174 critically ill 
      patients who had undergone hemodynamic monitoring by TDD. We calculated the 
      differences of simultaneous TD and TDD determined by ITBV or EVLW measurements. 
      Bias and standard deviations (SD) were calculated and extended Bland-Altman 
      regression analyses were performed. Association of the differences and the 
      potential confounders gender, age, PEEP, p(a)O(2)/F(I)O(2) ratio and the 
      corresponding TDD measurement were analyzed by multiple linear regression and 
      LOWESS regression. RESULTS: Overall results (bias+/-SD) were 1+/-58 ml/m(2) for 
      ITBV and 0.0+/-1.4 ml/kg bw for EVLW, but TD overestimated TDD results in 
      patients with higher ITBV and underestimated those for lower ITBV values. The 
      deviations were small, and the dependence of ITBV could be explained completely 
      by dependence on PEEP and age. However, low values of EVLW are overestimated by 
      TD. CONCLUSION: Single transpulmonary thermodilution for estimation of ITBV or 
      EVLW is reliable in patients with severe lung injury for normal and higher 
      values.
FAU - Hofmann, D
AU  - Hofmann D
AD  - Klinik fur Anasthesiologie und Intensivtherapie, Friedrich-Schiller-Universitat, 
      Jena.
FAU - Klein, M
AU  - Klein M
FAU - Wegscheider, K
AU  - Wegscheider K
FAU - Sakka, S G
AU  - Sakka SG
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Erweitertes hamodynamisches Monitoring mithilfe der transpulmonalen 
      Thermodilution. Einfluss verschiedener Faktoren auf die Genauigkeit der 
      Abschatzung von intrathorakalem Blutvolumen und extravaskularem Lungenwasser bei 
      kritisch kranken Patienten.
PL  - Germany
TA  - Anaesthesist
JT  - Der Anaesthesist
JID - 0370525
RN  - 0 (Indicators and Reagents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/physiology
MH  - Algorithms
MH  - Blood Volume Determination/*methods
MH  - Child
MH  - Child, Preschool
MH  - *Critical Illness
MH  - Data Interpretation, Statistical
MH  - Extravascular Lung Water/*physiology
MH  - Female
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Indicators and Reagents
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Physiologic/*methods
MH  - Pulmonary Circulation/*physiology
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Thermodilution/*methods
EDAT- 2005/02/24 09:00
MHDA- 2005/05/25 09:00
CRDT- 2005/02/24 09:00
PHST- 2005/02/24 09:00 [pubmed]
PHST- 2005/05/25 09:00 [medline]
PHST- 2005/02/24 09:00 [entrez]
AID - 10.1007/s00101-005-0809-2 [doi]
PST - ppublish
SO  - Anaesthesist. 2005 Apr;54(4):319-26. doi: 10.1007/s00101-005-0809-2.