PMID- 15728809
OWN - NLM
STAT- MEDLINE
DCOM- 20050228
LR  - 20220408
IS  - 1533-4406 (Electronic)
IS  - 0028-4793 (Linking)
VI  - 352
IP  - 8
DP  - 2005 Feb 24
TI  - A population-based study of primary human herpesvirus 6 infection.
PG  - 768-76
AB  - BACKGROUND: Serologic studies indicate that human herpesvirus 6 (HHV-6) infects 
      90 percent of children by two years of age. Little is known about the 
      acquisition, virologic course, and clinical manifestations of HHV-6 infection. 
      METHODS: We prospectively studied a cohort of 277 children from birth through the 
      first two years of life to define the pattern of acquisition of HHV-6. The 
      children's saliva was tested weekly for HHV-6 DNA with the use of the polymerase 
      chain reaction. Parents maintained a daily log of signs and symptoms of illness 
      in their children. RESULTS: Primary HHV-6 infection occurred in 130 children, 
      with cumulative percentages of 40 percent by the age of 12 months and 77 percent 
      by the age of 24 months. The peak age of acquisition was between 9 and 21 months. 
      The acquisition of HHV-6 was associated with female sex (adjusted hazard ratio, 
      1.7; 95 percent confidence interval, 1.2 to 2.4) and having older siblings 
      (adjusted hazard ratio, 2.1; 95 percent confidence interval, 1.4 to 2.9). Among 
      81 children with a well-defined time of acquisition of HHV-6, 93 percent had 
      symptoms, and 38 percent were seen by a physician. None had seizures. As compared 
      with children who had other illnesses, those with primary HHV-6 infection were 
      more likely to have fever (P=0.003), fussiness (P=0.02), diarrhea (P=0.03), rash 
      (P=0.003), and roseola (P=0.002) and were more likely to visit a physician 
      (P=0.003). CONCLUSIONS: The acquisition of HHV-6 in infancy is usually 
      symptomatic and often results in medical evaluation. Roseola occurs in a minority 
      of patients, and febrile seizures are infrequently associated with primary HHV-6 
      infection. Older siblings appear to serve as a source of HHV-6 transmission.
CI  - Copyright 2005 Massachusetts Medical Society.
FAU - Zerr, Danielle M
AU  - Zerr DM
AD  - Department of Pediatrics, University of Washington, Seattle, USA. 
      zerr@u.washington.edu
FAU - Meier, Amalia S
AU  - Meier AS
FAU - Selke, Stacy S
AU  - Selke SS
FAU - Frenkel, Lisa M
AU  - Frenkel LM
FAU - Huang, Meei-Li
AU  - Huang ML
FAU - Wald, Anna
AU  - Wald A
FAU - Rhoads, Margaret P
AU  - Rhoads MP
FAU - Nguy, Long
AU  - Nguy L
FAU - Bornemann, Rena
AU  - Bornemann R
FAU - Morrow, Rhoda Ashley
AU  - Morrow RA
FAU - Corey, Lawrence
AU  - Corey L
LA  - eng
GR  - AI-30731/AI/NIAID NIH HHS/United States
GR  - AI001679/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - N Engl J Med
JT  - The New England journal of medicine
JID - 0255562
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
CIN - N Engl J Med. 2005 Feb 24;352(8):753-5. PMID: 15728806
MH  - Antibodies, Viral/blood
MH  - Child, Preschool
MH  - DNA, Viral/analysis
MH  - Exanthema Subitum/diagnosis/epidemiology
MH  - Female
MH  - Fever/etiology
MH  - *Herpesvirus 6, Human/genetics/immunology/isolation & purification
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Polymerase Chain Reaction
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Factors
MH  - Roseolovirus Infections/complications/diagnosis/*epidemiology
MH  - Saliva/virology
MH  - Sex Factors
MH  - Survival Analysis
EDAT- 2005/02/25 09:00
MHDA- 2005/03/01 09:00
CRDT- 2005/02/25 09:00
PHST- 2005/02/25 09:00 [pubmed]
PHST- 2005/03/01 09:00 [medline]
PHST- 2005/02/25 09:00 [entrez]
AID - 352/8/768 [pii]
AID - 10.1056/NEJMoa042207 [doi]
PST - ppublish
SO  - N Engl J Med. 2005 Feb 24;352(8):768-76. doi: 10.1056/NEJMoa042207.