PMID- 15728986
OWN - NLM
STAT- MEDLINE
DCOM- 20060926
LR  - 20111117
IS  - 1344-6304 (Print)
IS  - 1344-6304 (Linking)
VI  - 58
IP  - 1
DP  - 2005 Feb
TI  - Polymorphisms of the HLA-B and HLA-DRB1 genes in Thai malaria patients.
PG  - 25-8
AB  - The high degree of polymorphism of human leukocyte antigen (HLA) genes has been 
      suggested to result from natural selection against susceptibility to a variety of 
      infectious pathogens, including malaria. HLA molecules are considered to play a 
      crucial role in the defense of the host against malarial infection, and different 
      HLA class I and class II alleles have been reported to be associated with reduced 
      susceptibility to malaria or the severity of malaria in different populations. To 
      test for associations between HLA alleles and the severity of malaria in a Thai 
      population, polymorphisms of HLA-B and HLA-DRB1 genes were investigated in 472 
      adult patients in northwest Thailand with Plasmodium falciparum malaria. In this 
      study, malaria patients were classified into three groups: mild malaria, 
      non-cerebral severe malaria, and cerebral malaria. Our results revealed that the 
      allele frequencies of HLA-B46, -B56, and -DRB1*1001 were statistically different 
      between non-cerebral severe malaria and cerebral malaria (P = 0.005), between 
      mild malaria and cerebral malaria (P = 0.032), and between mild malaria and 
      non-cerebral malaria (P = 0.007). However, our results may be showing false 
      positives due to multiple testing. Thus, further study with a larger sample size 
      must be conducted to obtain conclusive evidence of the association of these HLA-B 
      and DRB1 alleles with the severity of malaria in Thailand.
FAU - Hananantachai, Hathairad
AU  - Hananantachai H
AD  - Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
FAU - Patarapotikul, Jintana
AU  - Patarapotikul J
FAU - Ohashi, Jun
AU  - Ohashi J
FAU - Naka, Izumi
AU  - Naka I
FAU - Looareesuwan, Sornchai
AU  - Looareesuwan S
FAU - Tokunaga, Katsushi
AU  - Tokunaga K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Jpn J Infect Dis
JT  - Japanese journal of infectious diseases
JID - 100893704
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Malaria, Cerebral/immunology
MH  - Malaria, Falciparum/*immunology
MH  - *Polymorphism, Genetic
MH  - Thailand
EDAT- 2005/02/25 09:00
MHDA- 2006/09/27 09:00
CRDT- 2005/02/25 09:00
PHST- 2005/02/25 09:00 [pubmed]
PHST- 2006/09/27 09:00 [medline]
PHST- 2005/02/25 09:00 [entrez]
PST - ppublish
SO  - Jpn J Infect Dis. 2005 Feb;58(1):25-8.