PMID- 15730738
OWN - NLM
STAT- MEDLINE
DCOM- 20050902
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 43
IP  - 12
DP  - 2004 Dec
TI  - [A clinical and laboratory study of 11 cases of t(6;11)(q27;q23) acute leukemia].
PG  - 920-3
AB  - OBJECTIVE: To analyse the morphologic, immunophenotypic, cytogenetic and clinical 
      features of acute leukemia with t(6;11)(q27;q23). METHODS: Cytogenetic 
      examination of bone marrow cells was performed with direct method or 24 h culture 
      method. R-bands by heating using Giemsa (RHG) banding technique was used for 
      karyotype analysis. mixed lineage leukemia (MLL) rearrangement was detected by 
      interphase fluorescence in situ hybridization (FISH) using dual-color MLL probe 
      in 10 cases. Chromosome painting was performed by using whole chromosome paints 6 
      and 11 in 5 cases. RESULTS: t(6;11)(q27;q23) was predominantly found in acute 
      myeloid leukemia (AML)-M(5) (8/11 cases). Increased WBC between 10 and 100 x 
      10(9)/L was found in 9 cases. Liver, spleen and/or lymph node infiltrations were 
      found in 9 cases. t(6;11) as a sole abnormality was detected in 9 cases, However, 
      additional aberrations besides t(6;11) were detected in the other two cases. 
      Dual-color FISH analysis detected the MLL rearrangement in 10 cases. A reciprocal 
      translocation between 6 and 11 was proved by chromosome painting technique in 5 
      cases. The immunophenotypical analysis of leukemia cells showed co-expressed 
      myeloid and lymphocyte antigens in 4 cases. Blast cells were positive for CD(34) 
      antigen in 8 patients except case 8. Median survival was 6 months in this series. 
      CONCLUSIONS: t(6;11) acute leukemia had unique clinical features and a poor 
      prognosis. Chromosome painting technique and dual-color FISH are reliable tools 
      for detecting this translocation and MLL rearrangement respectively.
FAU - Pan, Jin-lan
AU  - Pan JL
AD  - The First Affiliated Hospital of Soochow University, Jiangsu Hematology Research 
      Institute, Suzhou 215006, China.
FAU - Xue, Yong-quan
AU  - Xue YQ
FAU - Jiang, Hai-yan
AU  - Jiang HY
FAU - Li, Tian-yu
AU  - Li TY
FAU - Wang, Yong
AU  - Wang Y
FAU - Qian, Jun
AU  - Qian J
FAU - Wu, Ya-fang
AU  - Wu YF
FAU - Wu, Tian-qin
AU  - Wu TQ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 6
MH  - Female
MH  - Gene Rearrangement
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Translocation, Genetic
EDAT- 2005/02/26 09:00
MHDA- 2005/09/03 09:00
CRDT- 2005/02/26 09:00
PHST- 2005/02/26 09:00 [pubmed]
PHST- 2005/09/03 09:00 [medline]
PHST- 2005/02/26 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2004 Dec;43(12):920-3.