PMID- 15732104
OWN - NLM
STAT- MEDLINE
DCOM- 20050425
LR  - 20091119
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 57
IP  - 3
DP  - 2005 Mar
TI  - Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG.
PG  - 444-8
AB  - In generalized myasthenia gravis (MG) patients without detectable acetylcholine 
      receptor (AChR) antibodies (SNMG), the thymus is often reported as "normally 
      involuted." We analyzed thymic compartments in 67 patients with generalized MG, 
      with AChR antibodies (AChR+, n = 23), with muscle-specific kinase (MuSK) 
      antibodies (MuSK+, n = 14) or with neither (MuSK-, n = 30), and in 11 non-MG 
      controls. Four of 14 MuSK+ thymi had rare small germinal centers, but overall 
      they were not different from age-matched controls. However, approximately 75% 
      MuSK- samples showed lymph node-type infiltrates similar to those in AChR+ 
      patients, but with fewer germinal centers. These variations may explain some 
      apparent differences in responses to thymectomy in SNMG.
FAU - Leite, Maria Isabel
AU  - Leite MI
AD  - Neurosciences Group, Department of Clinical Neurology, University of Oxford, 
      Oxford OX3 9DU, United Kingdom.
FAU - Strobel, Philipp
AU  - Strobel P
FAU - Jones, Margaret
AU  - Jones M
FAU - Micklem, Kingsley
AU  - Micklem K
FAU - Moritz, Regina
AU  - Moritz R
FAU - Gold, Ralf
AU  - Gold R
FAU - Niks, Erik H
AU  - Niks EH
FAU - Berrih-Aknin, Sonia
AU  - Berrih-Aknin S
FAU - Scaravilli, Francesco
AU  - Scaravilli F
FAU - Canelhas, Aurea
AU  - Canelhas A
FAU - Marx, Alexander
AU  - Marx A
FAU - Newsom-Davis, John
AU  - Newsom-Davis J
FAU - Willcox, Nick
AU  - Willcox N
FAU - Vincent, Angela
AU  - Vincent A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Antibodies)
RN  - 0 (Antigens, CD20)
RN  - 0 (Receptors, Cholinergic)
RN  - 0 (Receptors, Complement 3b)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies/*metabolism
MH  - Antigens, CD20/metabolism
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Middle Aged
MH  - Myasthenia Gravis/*immunology/pathology
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
MH  - Receptors, Complement 3b/metabolism
MH  - Thymus Gland/metabolism/*pathology
EDAT- 2005/02/26 09:00
MHDA- 2005/04/26 09:00
CRDT- 2005/02/26 09:00
PHST- 2005/02/26 09:00 [pubmed]
PHST- 2005/04/26 09:00 [medline]
PHST- 2005/02/26 09:00 [entrez]
AID - 10.1002/ana.20386 [doi]
PST - ppublish
SO  - Ann Neurol. 2005 Mar;57(3):444-8. doi: 10.1002/ana.20386.