PMID- 15732874
OWN - NLM
STAT- MEDLINE
DCOM- 20050315
LR  - 20211203
IS  - 0022-3492 (Print)
IS  - 0022-3492 (Linking)
VI  - 75
IP  - 12
DP  - 2004 Dec
TI  - In vitro biocompatibility of a new titanium-29niobium-13tantalum-4.6zirconium 
      alloy with osteoblast-like MG63 cells.
PG  - 1701-7
AB  - BACKGROUND: Titanium-29niobium-13tantalum-4.6zirconium (TiNb) has recently been 
      developed as a new implant material. TiNb is composed of non-toxic elements and 
      has a lower modulus of elasticity than the other titanium alloys. However, its 
      biocompatibility has not been adequately characterized. The aim of this study was 
      to evaluate the biocompatibility of TiNb using an osteoblast-titanium co-culture 
      system. METHODS: MG63 cells were cultured on three kinds of titanium disks: TiNb, 
      pure titanium (pTi), and titanium-6aluminum-4vanadium (TiAl), prepared with two 
      different surfaces, a polished and acid-etched surface and a machined-grooved 
      surface. The surface topography and roughness were evaluated by scanning electron 
      microscopy (SEM). After 48 hours culture, the number of proliferating cells and 
      prostaglandin E2 (PGE2) production in the culture supernatant were determined. 
      RESULTS: There was no significant difference in surface roughness among the three 
      titanium disks with a polished and acid-etched surface. After 48 hours of 
      culture, the number of cells was significantly reduced on pTi and TiAl compared 
      to TiNb and the control. PGE2 production was significantly higher on pTi than on 
      TiAl, TiNb, and the control. We further examined the effect of surface roughness 
      on PGE2 production using machine-grooved titanium disks. While pTi and TiAl 
      stimulated the production of PGE2 depending on surface roughness, roughened TiNb 
      did not affect PGE2 production. CONCLUSIONS: These results suggest that TiNb may 
      exhibit favorable biocompatibility because it has an efficient surface topography 
      for cell proliferation, and the level of PGE2 production does not depend on 
      surface roughness. We conclude that TiNb may be useful as an implant material.
FAU - Naganawa, T
AU  - Naganawa T
AD  - Department of Periodontology, School of Dentistry, Aichi-Gakuin University, 
      Nagoya-shi Aichi, Japan.
FAU - Ishihara, Y
AU  - Ishihara Y
FAU - Iwata, T
AU  - Iwata T
FAU - Koide, M
AU  - Koide M
FAU - Ohguchi, M
AU  - Ohguchi M
FAU - Ohguchi, Y
AU  - Ohguchi Y
FAU - Murase, Y
AU  - Murase Y
FAU - Kamei, H
AU  - Kamei H
FAU - Sato, N
AU  - Sato N
FAU - Mizuno, M
AU  - Mizuno M
FAU - Noguchi, T
AU  - Noguchi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Alloys)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Dental Alloys)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RANK Ligand)
RN  - 0 (Receptor Activator of Nuclear Factor-kappa B)
RN  - 0 (TNFRSF11A protein, human)
RN  - 0 (TNFSF11 protein, human)
RN  - 0 (Ti-29Nb-13Ta-4.6Zr alloy)
RN  - 05175J654G (Niobium)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - 6424HBN274 (Tantalum)
RN  - C6V6S92N3C (Zirconium)
RN  - D1JT611TNE (Titanium)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Alloys
MH  - Analysis of Variance
MH  - *Biocompatible Materials/pharmacology
MH  - Carrier Proteins/biosynthesis
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Coculture Techniques
MH  - Cytokines/biosynthesis
MH  - *Dental Alloys/pharmacology
MH  - Dental Polishing
MH  - Dinoprostone/biosynthesis
MH  - Humans
MH  - Materials Testing
MH  - Membrane Glycoproteins/biosynthesis
MH  - *Niobium/pharmacology
MH  - Osteoblasts/*drug effects/metabolism
MH  - RANK Ligand
MH  - Receptor Activator of Nuclear Factor-kappa B
MH  - Surface Properties
MH  - *Tantalum/pharmacology
MH  - *Titanium/pharmacology
MH  - *Zirconium/pharmacology
EDAT- 2005/03/01 09:00
MHDA- 2005/03/16 09:00
CRDT- 2005/03/01 09:00
PHST- 2005/03/01 09:00 [pubmed]
PHST- 2005/03/16 09:00 [medline]
PHST- 2005/03/01 09:00 [entrez]
AID - 10.1902/jop.2004.75.12.1701 [doi]
PST - ppublish
SO  - J Periodontol. 2004 Dec;75(12):1701-7. doi: 10.1902/jop.2004.75.12.1701.